2. Protein Tyrosine Kinase/RTK Metabolic Enzyme/Protease
  3. Anaplastic lymphoma kinase (ALK) Fat Mass and Obesity-associated Protein (FTO)
  4. DDO-02267

DDO-02267 是一种选择性的 ALKBH5 赖氨酸靶向共价抑制剂，IC50 值为 0.49 μM。DDO-02267 增加 N6-methyladenosine (m6A) 水平，并靶向 ALKBH5-AXL 信号轴。DDO-02267 可作为研究 mRNA 去甲基化酶生物功能的探针。

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DDO-02267 Chemical Structure

DDO-02267 Chemical Structure

CAS No. : 2919768-58-2

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DDO-02267 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DDO-02267 is a selective and lysine-targeting covalent inhibitor of ALKBH5, with an IC50 value of 0.49 μM. DDO-02267 increases N6-methyladenosine (m6A) levels and targets the ALKBH5-AXL signaling axis. DDO-02267 can serve as a probe for investigating the biological function of mRNA demethylase[1].

IC50 & Target

ALKBH5: 0.49 μM, ALKBH3: 11.71 μM, FTO: 14.16 μM
分子量

400.36

Formula

C18H12N2O7S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

DDO-02267 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DDO-022672919768-58-2DDO02267DDO 02267Anaplastic lymphoma kinase (ALK)Fat Mass and Obesity-associated Protein (FTO)Anaplastic lymphoma kinaseALK tyrosine kinase receptorCD246Cluster of differentiation 246AML，MOLM-13MigrationMultiple myelomaGlioblastomaBreast cancer.Inhibitorinhibitorinhibit

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产品名称：
DDO-02267
目录号：
HY-170668
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