DDR1-IN-6 

DDR1-IN-6 is a selective Discoidin Domain Receptor family, member 1 (DDR1) inhibitor with an IC₅₀ of 9.72 nM. DDR1-IN-6 inhibits auto-phosphorylation DDR1b (Y513) with an IC₅₀ of 9.7 nM. DDR1-IN-6 has anti-cancer activity^[1]. DDR1-IN-6 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

DDR1-IN-6 (compound 1; for 24 hours) inhibits collagen production in human hepatic stellate cell LX-2 (IC₅₀=13 nM)^[1].
DDR1-IN-6 (72 hours) has cytotoxicity in LX-2 cells (CC₅₀=3 μM)^[1].
DDR1-IN-6 (0-30 μM) has anti-proliferation effects on primary tumor cells freshly isolated from PC-07-0024 (IC₅₀=5.7 μM of 3 days; IC₅₀=2.65 μM of 6 days) and LU-01-0523 derived xenograft (PDX) tumor model (IC₅₀>30 μM of 3 days; IC₅₀>30 μM of 6 days)^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

433.39

C₂₃H₁₄F₃N₅O

2416021-47-9

固体

Light yellow to yellow

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

• [1]. Aleksandr M. Aliper, et al. Kinase inhibitors. WO2020079652A1.