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  4. Deac-SS-Biotin

Deac-SS-Biotin 是一种有效的抗癌剂。Deac-SS-Biotin 通过生物素介导的内吞作用摄取进入细胞。Deac-SS-Biotin 与 DTT (谷胱甘肽) 结合可有效抑制微管组装并显示出更强的抗肿瘤活性。

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Deac-SS-Biotin Chemical Structure

Deac-SS-Biotin Chemical Structure

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Deac-SS-Biotin 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Deac-SS-Biotin is a potent antitumor agent. Deac-SS-Biotin uptakes into the cells through biotin-mediated internalization. Deac-SS-Biotin combined with DTT (Glutathione mimetic) can effectively inhibit microtubule assembly and displays greater antitumor activity[1].

体外研究
(In Vitro)

Deac-SS-Biotin (compound 9) (5 µM; 24 h) has a remarkable reduction-responsive drug release[1].
Biotin effectively preventes Deac-SS-Biotin from binding to biotin receptor, thereby blocking the cellular uptake of Deac-SS-Biotin[1].
Deac-SS-Biotin (5 µM, 5 µM and 10 µM DTT; 0-80 min) effectively inhibits microtubule assembly and displays greater antitumor activity[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Deac-SS-Biotin 相关抗体:

Cell Proliferation Assay[1]

Cell Line: SGC-7901, A549, Hela, L929 cells
Concentration: 0-20 µM
Incubation Time: 72 h
Result: Showed potent antiproliferative activity with IC50s of 0.124, 0.085, 0.108, 4.22 µM for SGC-7901, A549, Hela, L929 cells.

Cell Viability Assay[1]

Cell Line: A549 cells
Concentration: 0.17 µM
Incubation Time:
Result: Increased the cell viability from 23.6% to 68.9% with the increase of biotin concentration from 0.075 to 0.60 µM.
分子量

763.94

Formula

C35H45N3O10S3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Deac-SS-Biotin 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Deac-SS-BiotinOthersAntitumoranti-tubulinbiotinA549 cellsantiproliferativeselectiveInhibitorinhibitorinhibit

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