2. Vitamin D Related/Nuclear Receptor Others
  3. Thyroid Hormone Receptor Isotope-Labeled Compounds
  4. Debutyldronedarone-d7 hydrochloride

Debutyldronedarone-d7 hydrochloride  (Synonyms: SR35021-d7 hydrochloride)

目录号: HY-12753AS
产品使用指南

摩尔计算器

Debutyldronedarone-d7 hydrochloride 是氘代标记的 Debutyldronedarone hydrochloride (HY-12753A)。Debutyldronedarone (SR35021) hydrochloride 是 Dronedarone 的主要代谢物，是一种选择性的甲状腺激素受体 α1 (TRα1) 抑制剂。Debutyldronedarone hydrochloride 抑制 T3 与 TRα1 和 TRβ1 的结合，抑制率分别为 77% 和 25%。Debutyldronedarone hydrochloride 可用于心律失常的研究。

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Debutyldronedarone-d<sub>7</sub> hydrochloride Chemical Structure

Debutyldronedarone-d7 hydrochloride Chemical Structure

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Other Forms of Debutyldronedarone-d7 hydrochloride:

Debutyldronedarone-d7 hydrochloride 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Debutyldronedarone-d7 hydrochloride is deuterated labeled Debutyldronedarone hydrochloride (HY-12753A). Debutyldronedarone (SR35021) hydrochloride, the main metabolite of Dronedarone, is a selective thyroid hormone receptor α1 (TRα1) inhibitor. Debutyldronedarone hydrochloride inhibits T3 binding to TRα1 and TRβ1 by 77% and 25%, respectively. Debutyldronedarone hydrochloride can be used for the research of arrhythmic[1].

体外研究
(In Vitro)

氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注，因为它可能影响药物的药代动力学和代谢谱[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Debutyldronedarone-d7 hydrochloride 相关抗体:
分子量

544.15

Formula

C27H30D7ClN2O5S
非标记 CAS

197431-02-0
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Debutyldronedarone-d7 hydrochloride 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Debutyldronedarone-d7SR35021-d7Thyroid Hormone ReceptorIsotope-Labeled CompoundsTHRarrhythmicRβ1DronedaronemetaboliteselectiveInhibitorinhibitorinhibit

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