DEC-RVRK-CMK  (Synonyms: Decanoyl-Arg-Val-Arg-Lys-chloromethylketone)

DEC-RVRK-CMK (Decanoyl-Arg-Val-Arg-Lys-chloromethylketone) is a peptide-based CMK (chloromethylketone) inhibitor that targets and inactivates the secreted soluble kexin (Kex2) (K_i=8.45 μM). The yeast enzyme Kex2 (kexin, EC 3.4.21.61) is a calcium-dependent transmembrane protease and belongs to the mammalian protease family of the serine protease subtilisin family. The binding mechanism of Kex2 with different CMK inhibitors depends on substrate selectivity, particularly the selective differences between lysine and arginine at the P1 position^[1].

Ki: 8.45 μM (ssKex2)^[1]

744.41

C₃₄H₆₆ClN₁₁O₅

534615-50-4

{DEC}-Arg-Val-Arg-Lys-{CMK}

{DEC}-RVRK-{CMK}

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Wheatley JL, et al. Differential P1 arginine and lysine recognition in the prototypical proprotein convertase Kex2. Proc Natl Acad Sci U S A. 2007 Apr 17;104(16):6626-31.  [Content Brief]