2. Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor
  3. LXR
  4. Dendrogenin A

Dendrogenin A  (Synonyms: DDA)

目录号: HY-149132
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摩尔计算器

Dendrogenin A (DDA) 是肝 X 受体 (LXR) 的配体，可诱导钠/碘共转运体 (NIS) 的表达，并增加碘的吸收。Dendrogenin A 可诱导 MCF-7 细胞分化，并重新激活哺乳细胞的功能。Dendrogenin A 可诱导 TSH 受体、甲状腺过氧化物酶和甲状腺球蛋白的表达，并影响甲状腺激素的生成。Dendrogenin A 在癌细胞 B-CPAP 和 8505c 中表现出细胞毒性，IC50 分别为 4.1 和 6.2 µM。Dendrogenin A 可在 G0/G1 期阻滞细胞周期。

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Dendrogenin A Chemical Structure

Dendrogenin A Chemical Structure

CAS No. : 1191043-85-2

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Dendrogenin A 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Dendrogenin A (DDA) is a ligand for liver X receptor (LXR), that induces the expression of sodium/iodine symporter, and increases iodine uptake. Dendrogenin A induces cell differentiation of MCF-7, and reactivates the function of lactating cells. Dendrogenin A induces the expressions of the TSH receptor, thyroid peroxidase, and thyroglobulin, and affects thyroid hormone generation. Dendrogenin A exhibits cytotoxicity in cancer cell B-CPAP and 8505c with IC50 of 4.1 and 6.2 µM. Dendrogenin A arrests the cell cycle at G0/G1 phase[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
2.56 μM
Compound: 14, Dendrogenin A
Cytotoxicity against human A549 cells after 72 hrs by trypan blue exclusion assay
Cytotoxicity against human A549 cells after 72 hrs by trypan blue exclusion assay
[PMID: 19821610]
B16-F10 IC50
0.68 μM
Compound: 14, Dendrogenin A
Cytotoxicity against mouse B16F10 cells after 72 hrs by trypan blue exclusion assay
Cytotoxicity against mouse B16F10 cells after 72 hrs by trypan blue exclusion assay
[PMID: 19821610]
HCT-8 IC50
0.89 μM
Compound: 14, Dendrogenin A
Cytotoxicity against human HCT8 cells after 72 hrs by trypan blue exclusion assay
Cytotoxicity against human HCT8 cells after 72 hrs by trypan blue exclusion assay
[PMID: 19821610]
KG-1 IC50
5.53 μM
Compound: 14, Dendrogenin A
Cytotoxicity against human KG1 cells after 72 hrs by trypan blue exclusion assay
Cytotoxicity against human KG1 cells after 72 hrs by trypan blue exclusion assay
[PMID: 19821610]
MCF7 IC50
2.31 μM
Compound: 14, Dendrogenin A
Cytotoxicity against human MCF7 cells after 72 hrs by trypan blue exclusion assay
Cytotoxicity against human MCF7 cells after 72 hrs by trypan blue exclusion assay
[PMID: 19821610]
N2a IC50
2.32 μM
Compound: 14, Dendrogenin A
Cytotoxicity against mouse Neuro2a cells after 72 hrs by trypan blue exclusion assay
Cytotoxicity against mouse Neuro2a cells after 72 hrs by trypan blue exclusion assay
[PMID: 19821610]
NB-4 IC50
1.32 μM
Compound: 14, Dendrogenin A
Cytotoxicity against human NB4 cells after 72 hrs by trypan blue exclusion assay
Cytotoxicity against human NB4 cells after 72 hrs by trypan blue exclusion assay
[PMID: 19821610]
P19 IC50
1.8 μM
Compound: 14, Dendrogenin A
Cytotoxicity against mouse P19 cells after 72 hrs by trypan blue exclusion assay
Cytotoxicity against mouse P19 cells after 72 hrs by trypan blue exclusion assay
[PMID: 19821610]
P19 IC50
2.4 μM
Compound: 14, Dendrogenin A
Cytotoxicity against mouse P19 cells after 3 days by trypan blue exclusion assay
Cytotoxicity against mouse P19 cells after 3 days by trypan blue exclusion assay
[PMID: 19821610]
SH-SY5Y IC50
1.35 μM
Compound: 14, Dendrogenin A
Cytotoxicity against human SH-SY5Y cells after 72 hrs by trypan blue exclusion assay
Cytotoxicity against human SH-SY5Y cells after 72 hrs by trypan blue exclusion assay
[PMID: 19821610]
SK-MEL-28 IC50
2.12 μM
Compound: 14, Dendrogenin A
Cytotoxicity against human SK-MEL-28 cells after 72 hrs by trypan blue exclusion assay
Cytotoxicity against human SK-MEL-28 cells after 72 hrs by trypan blue exclusion assay
[PMID: 19821610]
SK-N-SH IC50
2.24 μM
Compound: 14, Dendrogenin A
Cytotoxicity against human SK-N-SH cells after 72 hrs by trypan blue exclusion assay
Cytotoxicity against human SK-N-SH cells after 72 hrs by trypan blue exclusion assay
[PMID: 19821610]
SW-620 IC50
0.42 μM
Compound: 14, Dendrogenin A
Cytotoxicity against human SW620 cells after 72 hrs by trypan blue exclusion assay
Cytotoxicity against human SW620 cells after 72 hrs by trypan blue exclusion assay
[PMID: 19821610]
TS/A IC50
1.28 μM
Compound: 14, Dendrogenin A
Cytotoxicity against mouse TSA cells after 72 hrs by trypan blue exclusion assay
Cytotoxicity against mouse TSA cells after 72 hrs by trypan blue exclusion assay
[PMID: 19821610]
U-87MG ATCC IC50
0.74 μM
Compound: 14, Dendrogenin A
Cytotoxicity against human U87 cells after 72 hrs by trypan blue exclusion assay
Cytotoxicity against human U87 cells after 72 hrs by trypan blue exclusion assay
[PMID: 19821610]
U-937 IC50
0.79 μM
Compound: 14, Dendrogenin A
Cytotoxicity against human U937 cells after 72 hrs by trypan blue exclusion assay
Cytotoxicity against human U937 cells after 72 hrs by trypan blue exclusion assay
[PMID: 19821610]
U-937 IC50
0.8 μM
Compound: 14, Dendrogenin A
Cytotoxicity against human U937 cells after 3 days by trypan blue exclusion assay
Cytotoxicity against human U937 cells after 3 days by trypan blue exclusion assay
[PMID: 19821610]
分子量

513.80

Formula

C32H55N3O2
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Dendrogenin A 相关分类

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Keywords:

Dendrogenin A1191043-85-2DDALXRLiver X receptorMCF-7breast cancerthyroid cancerB-CPAP8505cInhibitorinhibitorinhibit

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