2. GPCR/G Protein
  3. GCGR
  4. Des His1, Glu8 Exendin-4

Des His1, Glu8 Exendin-4 是一种有效的胰高血糖素样肽-1 受体 (GLP-1-R) 拮抗剂。Des His1, Glu8 Exendin-4 通过调节胰岛素分泌和葡萄糖产生来改善葡萄糖稳态。Des His1, Glu8 Exendin-4 可用于 2 型糖尿病和胃肠道的研究。

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Custom Peptide Synthesis

Des His1, Glu8 Exendin-4 Chemical Structure

Des His1, Glu8 Exendin-4 Chemical Structure

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Des His1, Glu8 Exendin-4 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Des His1, Glu8 Exendin-4 is a potent glucagon-like peptide-1 receptor (GLP-1-R) antagonist. Des His1, Glu8 Exendin-4 improves glucose homeostasis by regulating both insulin secretion and glucose production. Des His1, Glu8 Exendin-4 can be used for the research of type 2 diabetic and gastrointestinal[1].

体内研究
(In Vivo)

Des His1, Glu8 Exendin-4 (dH-EX) (i3vt injection; 50 μg, 2 μL/15 s) improves glucose homeostasis by regulating both insulin secretion and glucose production[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rat[1]
Dosage: 50 μg, 2 μl/15 s
Administration: i3vt injection
Result: Showed hyperglycemic for the first 45 min after the intraperitoneal glucose load.
Significantly increased insulin levels and insulin area under the curve (AUC) during the IVGTT.
分子量

4063.46

Formula

C179H277N47O59S
Sequence Shortening

GEGTFTSELSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Des His1, Glu8 Exendin-4 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Des His1, Glu8 Exendin-4GCGRGlucagon Receptorglucagon-like peptide-1 receptor (GLP-1-R)glucose homeostasisinsulinglucosetype 2 diabeticgastrointestinalInhibitorinhibitorinhibit

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