2. Metabolic Enzyme/Protease Anti-infection
  3. Dihydrofolate reductase (DHFR) Bacterial
  4. DHFR-IN-17

DHFR-IN-17 (compound j9) 是一种具有口服活性的 SaDHFR 抑制剂，其 IC50 值为 0.97 nM。DHFR-IN-17 对金黄色葡萄球菌具有抑菌活性，最低抑菌浓度为 0.031 μg/mL。

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DHFR-IN-17 Chemical Structure

DHFR-IN-17 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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DHFR-IN-17 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DHFR-IN-17 (compound j9) is an oral active SaDHFR inhibitor with the IC50 of 0.97 nM. DHFR-IN-17 shows antibacterial activity against S. aureus with the minimum inhibitory concentration of 0.031 μg/mL[1].

体内研究
(In Vivo)

DHFR-IN-17 (compound j9) (2、5、10mg/kg，连续灌胃 3 天)可减轻 MRSA 诱导的 C57 小鼠表皮感染的皮肤感染损伤[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MRSA-induced epidermal infections in C57 mice[1]
Dosage: 2、5 and 10mg/kg
Administration: Oral gavagefor 3 consecutive days
Result: Alleviates the skin infection damage.
分子量

440.28

Formula

C17H21IN4O2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

DHFR-IN-17 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DHFR-IN-17Dihydrofolate reductase (DHFR)BacterialStaphylococcus aureus infectionantibacterialInhibitorinhibitorinhibit

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产品名称：
DHFR-IN-17
目录号：
HY-162358
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