1. Metabolic Enzyme/Protease Cell Cycle/DNA Damage
  2. Dihydroorotate Dehydrogenase DNA/RNA Synthesis
  3. DHODH-IN-14

DHODH-IN-14 (Compound 7l) 是一种 A771726 的 hydroxyfurazan 类似物。DHODH-IN-14 是一种二氢乳清酸脱氢酶 (DHODH) 抑制剂,对大鼠肝脏 DHODHIC50 为 0.49 μM。DHODH-IN-14 可用于类风湿关节炎。

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DHODH-IN-14 Chemical Structure

DHODH-IN-14 Chemical Structure

CAS No. : 1364791-93-4

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规格 价格 是否有货 数量
1 mg ¥2207
1 - 2 周
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Customer Review

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DHODH-IN-14 (Compound 7l) is a hydroxyfurazan analog of A771726. DHODH-IN-14 is a dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 0.49 μM for rat liver DHODH. DHODH-IN-14 can be used for rheumatoid arthritis[1].

IC50 & Target

IC50: 0.49 μM (Rat liver DHODH)[1]

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
Jurkat IC50
59.7 μM
Compound: 2
Antiproliferative activity against human Jurkat T cells assessed as DNA content after 72 hrs by Hoechst 33258 dye based fluorometric method
Antiproliferative activity against human Jurkat T cells assessed as DNA content after 72 hrs by Hoechst 33258 dye based fluorometric method
[PMID: 28235702]
体外研究
(In Vitro)

DHODH-IN-14 (Compound 7l) is a hydroxyfurazan analog of A771726, in which the biphenyl scaffold with fluoro substituents. Moving to derivatives DHODH-IN-14, no major differences were observed among the poses obtained on 1UUO and 1D3G; in both cases DHODH-IN-14 is found to bind in a BQN-like fashion, namely with the deprotonated hydroxyfurazan moiety facing Arg136, thus effectively mimicking the carboxyl group of BQN and related compounds. While on 1D3G and 1UUO the hydroxyfurazan is in no case found to interact with Tyr356 in a Leflunomide-like fashion, a significant fraction of such poses is found when 2BXV is used as the docking target[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

353.23

Formula

C15H7F4N3O3

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

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产品名称:
DHODH-IN-14
目录号:
HY-135678
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