2. Metabolic Enzyme/Protease Cell Cycle/DNA Damage
  3. Dihydroorotate Dehydrogenase DNA/RNA Synthesis
  4. DHODH-IN-15

DHODH-IN-15 (Compound 7b) 是一种 A771726 的 hydroxyfurazan 类似物。DHODH-IN-15 是一种二氢乳清酸脱氢酶 (DHODH) 抑制剂，对大鼠肝脏 DHODH 的 IC50 为 11 μM。DHODH-IN-15 可用于类风湿关节炎。

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DHODH-IN-15 Chemical Structure

DHODH-IN-15 Chemical Structure

CAS No. : 1364791-88-7

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规格 价格 是否有货 数量
1 mg ￥2207
1 - 2 周
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DHODH-IN-15 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DHODH-IN-15 (Compound 7b) is a hydroxyfurazan analog of A771726. DHODH-IN-15 is a dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 11 μM for rat liver DHODH. DHODH-IN-15 can be used for rheumatoid arthritis[1].

IC50 & Target

IC50: 11 μM (Rat liver DHODH)[1]
体外研究
(In Vitro)

DHODH-IN-15 (Compound 7b) is a hydroxyfurazan analog of A771726, in which the biphenyl scaffold does not bear any substituent. Moving to derivatives DHODH-IN-15, no major differences were observed among the poses obtained on 1UUO and 1D3G; in both cases DHODH-IN-15 is found to bind in a BQN-like fashion, namely with the deprotonated hydroxyfurazan moiety facing Arg136, thus effectively mimicking the carboxyl group of BQN and related compounds. While on 1D3G and 1UUO the hydroxyfurazan is in no case found to interact with Tyr356 in a Leflunomide-like fashion, a significant fraction of such poses is found when 2BXV is used as the docking target[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

DHODH-IN-15 相关抗体:
分子量

281.27

Formula

C15H11N3O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

DHODH-IN-15 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DHODH-IN-151364791-88-7Dihydroorotate DehydrogenaseDNA/RNA SynthesisDHODHhydroxyfurazanLeflunomideA771726BQNratantiinflammatoryrheumatoidarthritisInhibitorinhibitorinhibit

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