2. Anti-infection
  3. Fungal Bacterial
  4. Di-O-methylhonokiol

Di-O-methylhonokiol 是一种可以从玉兰花中分离出来的天然酚类化合物。Di-O-methylhonokiol 对革兰氏阳性菌、抗酸杆菌和酵母样及丝状真菌具有显著的抗菌活性。Di-O-methylhonokiol 可用于真菌感染的研究。

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Di-O-methylhonokiol Chemical Structure

Di-O-methylhonokiol Chemical Structure

CAS No. : 68592-18-7

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5 mg ￥2400
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10 mg ￥3800
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Di-O-methylhonokiol 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Di-O-methylhonokiol is a natural phenolic compound that can be isolated from magnolia flowers. Di-O-methylhonokiol has significant antibacterial activity against Gram-positive bacteria, acid-fast bacilli, and yeast-like and filamentous fungi. Di-O-methylhonokiol can be used in the study of fungal infections[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
CNE2Z IC50
> 50 μM
Compound: 1c
Antiproliferative activity against human CNE2Z cells assessed as growth inhibition after 72 hrs by MTT assay
Antiproliferative activity against human CNE2Z cells assessed as growth inhibition after 72 hrs by MTT assay
[PMID: 31831382]
HepG2 IC50
> 135.98 μM
Compound: 9i
Antiproliferative activity against human HepG2 cells after 24 hrs by MTT assay
Antiproliferative activity against human HepG2 cells after 24 hrs by MTT assay
[PMID: 21853991]
HUVEC IC50
> 100 μM
Compound: 9i
Antiproliferative activity against human HUVEC cells after 24 hrs by MTT assay
Antiproliferative activity against human HUVEC cells after 24 hrs by MTT assay
[PMID: 21853991]
I10 IC50
> 50 μM
Compound: 1c
Antiproliferative activity against mouse I10 cells assessed as growth inhibition after 72 hrs by MTT assay
Antiproliferative activity against mouse I10 cells assessed as growth inhibition after 72 hrs by MTT assay
[PMID: 31831382]
Lewis lung carcinoma cell line IC50
> 136 μM
Compound: 9i
Antiproliferative activity against mouse LL/2 cells after 24 hrs by MTT assay
Antiproliferative activity against mouse LL/2 cells after 24 hrs by MTT assay
[PMID: 21853991]
MCF7 IC50
> 50 μM
Compound: 1c
Antiproliferative activity against human MCF7 cells assessed as growth inhibition after 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as growth inhibition after 72 hrs by MTT assay
[PMID: 31831382]
Oocyte EC50
42.1 μM
Compound: 13
Modulation of GABA Aalpha1beta2 receptor expressed in Xenopus laevis oocytes assessed as potentiation of GABA-induced chloride current at holding potential -70 mV by two-microelectrode voltage clamp technique
Modulation of GABA Aalpha1beta2 receptor expressed in Xenopus laevis oocytes assessed as potentiation of GABA-induced chloride current at holding potential -70 mV by two-microelectrode voltage clamp technique
[PMID: 21699169]
RAW264.7 IC50
> 100 μM
Compound: 5
Cytotoxicity against mouse RAW264.7 cells assessed as cell viability by propidium iodide staining based FACS-flow cytometry
Cytotoxicity against mouse RAW264.7 cells assessed as cell viability by propidium iodide staining based FACS-flow cytometry
[PMID: 22494844]
RAW264.7 IC50
40 μM
Compound: 5
Inhibition of LPS-induced NO production in mouse RAW264.7 cells after 24 hrs by Griess assay
Inhibition of LPS-induced NO production in mouse RAW264.7 cells after 24 hrs by Griess assay
[PMID: 22494844]
分子量

294.39

Formula

C20H22O2
CAS 号
性状

固体

颜色

White to off-white

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

纯度 & 产品资料
参考文献

Di-O-methylhonokiol 相关分类

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  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Di-O-methylhonokiol68592-18-7FungalBacterialNatural compoundMagnoliaGram-positive bacteriaantifungalInhibitorinhibitorinhibit

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