2. Metabolic Enzyme/Protease
  3. Liposome
  4. Diamino lipid DAL4

Diamino lipid DAL4 是一种氨基脂质，可用于制备新型脂质纳米颗粒 (LNPs)，包裹编码 IL-12、IL-27 和 GM-CSF 等细胞因子的 mRNA。Diamino lipid DAL4 能够传递细胞因子 mRNA 给肿瘤细胞，发挥抗肿瘤效力。

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Diamino lipid DAL4 Chemical Structure

Diamino lipid DAL4 Chemical Structure

CAS No. : 2939000-43-6

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Diamino lipid DAL4 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Diamino lipid DAL4 is diamino lipid for the preparation of lipid nanoparticles (LNPs) encapsulated with mRNAs encoding cytokines including IL-12, IL-27 and GM-CSF. Diamino lipid DAL4 delivers mRNA to tumor cells to exert anti-tumor activity[1].

体外研究
(In Vitro)

Diamino lipid DAL4 (DAL4-LNP) effectively delivers different mRNAs in vitro to tumor cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Diamino lipid DAL4 相关抗体:
体内研究
(In Vivo)

Diamino lipid DAL4 (DAL4-LNP) loaded with IL-12 mRNA (intratumoral injection) is most potent in inhibiting B16F10 melanoma tumor growth compared to IL-27 or GM-CSF mRNAs in monotherapy[1].
Diamino lipid DAL4 loaded with IL-12 mRNA and IL-27 mRNA (intratumoral injection) shows synergistic effect in suppressing tumor growth without causing systematic toxicity[1].
And also Diamino lipid DAL4 induces robust infiltration of immune effector cells, including IFN-γ and TNF-α producing natural killer cells (NK) and CD8+ T cells into tumors[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

844.17

Formula

C52H99BFN3O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Diamino lipid DAL4 相关分类

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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Diamino lipid DAL42939000-43-6Diamino lipid DAL 4Diamino lipid DAL-4Liposomelipid nanoparticlecytokinesIL-12IL-27GM-CSFantitumor activityInhibitorinhibitorinhibit

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Diamino lipid DAL4
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