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Diaziquone  (Synonyms: 亚丝醌; NSC 182986)

目录号: HY-119969 纯度: 98.46%
COA 产品使用指南

摩尔计算器

Diaziquone (Diaziquone) 是一种水溶性的合成的氮杂环苯醌，具有潜在的抗肿瘤活性。

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Diaziquone Chemical Structure

Diaziquone Chemical Structure

CAS No. : 57998-68-2

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规格 价格 是否有货 数量
1 mg ￥1470
In-stock
5 mg ￥3640
In-stock
10 mg ￥5320
In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Customer Review

Diaziquone 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Diaziquone (Diaziquone) is a water-soluble, synthetic aziridinylbenzoquinone with potential antineoplastic activity[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
BJ EC50
< 10 μM
Compound: diaziquone
Cytotoxicity against human BJ cells assessed as viable cells after 72 hrs by calcein AM assay
Cytotoxicity against human BJ cells assessed as viable cells after 72 hrs by calcein AM assay
[PMID: 20192247]
CCRF-CEM EC50
0.86 μM
Compound: diaziquone
Cytotoxicity against human CEM cells assessed as viable cells after 72 hrs by calcein AM assay
Cytotoxicity against human CEM cells assessed as viable cells after 72 hrs by calcein AM assay
[PMID: 20192247]
HeLa EC50
6.4 μM
Compound: diaziquone
Cytotoxicity against human HeLa cells assessed as viable cells after 72 hrs by calcein AM assay
Cytotoxicity against human HeLa cells assessed as viable cells after 72 hrs by calcein AM assay
[PMID: 20192247]
MCF7 EC50
4 μM
Compound: diaziquone
Cytotoxicity against human MCF7 cells assessed as viable cells after 72 hrs by calcein AM assay
Cytotoxicity against human MCF7 cells assessed as viable cells after 72 hrs by calcein AM assay
[PMID: 20192247]
RPMI-8226 EC50
3.4 μM
Compound: diaziquone
Cytotoxicity against human RPMI8226 cells assessed as viable cells after 72 hrs by calcein AM assay
Cytotoxicity against human RPMI8226 cells assessed as viable cells after 72 hrs by calcein AM assay
[PMID: 20192247]
U-266 EC50
2.8 μM
Compound: diaziquone
Cytotoxicity against human U266 cells assessed as viable cells after 72 hrs by calcein AM assay
Cytotoxicity against human U266 cells assessed as viable cells after 72 hrs by calcein AM assay
[PMID: 20192247]
体内研究
(In Vivo)

Diaziquone (6.75mg /sq m daily for 5 consecutive days or single-dose 26 mg/sq m) has a broad range of activity of diaziquone against primary nervous system tumors and has enhancement effect combined with either 1,3-bis(2-chloroethyl)-1-nitrosourea or procarbazine in athymic mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Homozygous nu/nu BALB/c athymic mice[1]
Dosage: 6.75mg /sq m or 26 mg/sq m
Administration: 6.75mg /sq m daily for 5 consecutive days or single-dose 26 mg/sq m
Result: Showed rapid clearance in the plasma of athymic mice with a half-life of approximately 11.5 min.
Produced significant growth delays.
Produced significant increases in the median growth delay, significant increases in the number of tumor regressions.
分子量

364.35

Formula

C16H20N4O6
CAS 号
性状

固体

颜色

Light yellow to brown

中文名称

亚丝醌
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 125 mg/mL (343.08 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.7446 mL 13.7231 mL 27.4461 mL
5 mM 0.5489 mL 2.7446 mL 5.4892 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Diaziquone 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7446 mL 13.7231 mL 27.4461 mL 68.6153 mL
5 mM 0.5489 mL 2.7446 mL 5.4892 mL 13.7231 mL
10 mM 0.2745 mL 1.3723 mL 2.7446 mL 6.8615 mL
15 mM 0.1830 mL 0.9149 mL 1.8297 mL 4.5744 mL
20 mM 0.1372 mL 0.6862 mL 1.3723 mL 3.4308 mL
25 mM 0.1098 mL 0.5489 mL 1.0978 mL 2.7446 mL
30 mM 0.0915 mL 0.4574 mL 0.9149 mL 2.2872 mL
40 mM 0.0686 mL 0.3431 mL 0.6862 mL 1.7154 mL
50 mM 0.0549 mL 0.2745 mL 0.5489 mL 1.3723 mL
60 mM 0.0457 mL 0.2287 mL 0.4574 mL 1.1436 mL
80 mM 0.0343 mL 0.1715 mL 0.3431 mL 0.8577 mL
100 mM 0.0274 mL 0.1372 mL 0.2745 mL 0.6862 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Diaziquone57998-68-2NSC 182986亚丝醌NSC182986NSC-182986Othersantitumorwater-solubleaziridinylbenzoquinonecancerInhibitorinhibitorinhibit

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