2. Antibody-drug Conjugate/ADC Related
  3. ADC Cytotoxin
  4. Dimethyl-SGD-1882

Dimethyl-SGD-1882  (Synonyms: Dimethyl-PBD dimer)

目录号: HY-126678
产品使用指南

摩尔计算器

Dimethyl-SGD-1882 (Dimethyl-PBD dimer) 是一种高效的 DNA 烷化剂 (DNA alkylator)，可作用做抗体偶联药物 (ADC) 的毒素部分。PBD Dimer 是一种 DNA 烷化剂，能抑制 DNA 复制。

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Dimethyl-SGD-1882 Chemical Structure

Dimethyl-SGD-1882 Chemical Structure

CAS No. : 3026416-27-0

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Dimethyl-SGD-1882 相关抗体

Top Publications Citing Use of Products

查看 ADC Cytotoxin 亚型特异性产品:

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Auristatin Calicheamicins Camptothecins Daunorubicins/Doxorubicins Duocarmycins Maytansinoids Pyrrolobenzodiazepines Traditional Cytotoxic Agents

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Dimethyl-SGD-1882 (Dimethyl-PBD dimer) is a highly potent DNA alkylator, and is used as an antibody-drug conjugate (ADC) cytotoxin. PBD Dimer is a DNA alkylator which inhibits DNA replication[1].

IC50 & Target[1]

Pyrrolobenzodiazepines

 

体外研究
(In Vitro)

The unique structure of the pyrrolobenzodiazepine (PBD) dimers which contain two alkylating imine functionalities allows them to form interstrand or intrastrand DNA cross‐links in addition to mono‐alkylated adducts, thus resulting in greater DNA stabilization compared to monomeric PBDs. Due to the additional types of DNA adducts possible and the greater adduct stability, the C8‐linked PBD dimers generally have significantly greater cytotoxicity, antitumor activity and antibacterial activity compared to PBD monomers, and one such agent, SJG‐136, has reached Phase II clinical trials in ovarian cancer and leukaemia. Furthermore, related PBD dimers are now being used as payloads for antibody-drug conjugates (ADCs) due to their significant cytotoxicity[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Dimethyl-SGD-1882 相关抗体:
分子量

753.84

Formula

C44H43N5O7
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Dimethyl-SGD-1882 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dimethyl-SGD-18823026416-27-0Dimethyl-PBD dimerADC CytotoxinADC PayloadInhibitorinhibitorinhibit

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