Dinoprost-¹³C₅  (Synonyms: 地诺前列素-¹³C₅; Prostaglandin F2α-¹³C5; PGF2α-¹³C₅)

Dinoprost-¹³C₅ is ¹³C labeled Dinoprost (HY-12956). Dinoprost (Prostaglandin F2α) is an orally active, potent prostaglandin F (PGF) receptor (FP receptor) agonist. Dinoprost is a luteolytic hormone produced locally in the endometrial luminal epithelium and corpus luteum (CL). Dinoprost plays a key role in the onset and progression of labour^[1][2].

氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注，因为它可能影响药物的药代动力学和代谢谱^[1]。
Dinoprost (Prostaglandin F2α；1 μM；持续 24 小时) 在山羊黄体细胞中诱导内质网应激、自噬和细胞凋亡^[2]。
Dinoprost (1 μM；持续 24 小时) 显著增加 GRP78 和 UPR 传感器的表达^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

352.39

C₁₅¹³C₅H₂₇O₅

551-11-1

地诺前列素-¹³C₅；前列腺素 F2a-¹³C₅

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  [Content Brief]

  [2]. Hagen Thieme, et al. Endothelin antagonism: effects of FP receptor agonists prostaglandin F2alpha and fluprostenol on trabecular meshwork contractility. Invest Ophthalmol Vis Sci. 2006 Mar;47(3):938-45.  [Content Brief]

  [3]. Xin Wen, et al. Prostaglandin F2α Induces Goat Corpus Luteum Regression via Endoplasmic Reticulum Stress and Autophagy. Front Physiol. 2020 Sep 11;11:868.  [Content Brief]