2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. iGluR
  4. DL-AP5 lithium

DL-AP5 lithium  (Synonyms: 2-APV lithium; DL-2-Amino-5-phosphonovaleric acid lithium)

目录号: HY-100714D
产品使用指南 技术支持

DL-AP5 (2-APV) lithium 是一种竞争性的 NMDA (N-methyl-D-aspartate) 受体拮抗剂。DL-AP5 lithium 表现出明显的镇痛活性。DL-AP5 lithium 可特异性阻断兔视网膜的通道。

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DL-AP5 lithium Chemical Structure

DL-AP5 lithium Chemical Structure

CAS No. : 125229-62-1

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DL-AP5 lithium 的其他形式现货产品:

Other Forms of DL-AP5 lithium:

DL-AP5 lithium 相关抗体

Top Publications Citing Use of Products

    DL-AP5 lithium purchased from MCE. Usage Cited in: CNS Neurosci Ther. 2022 Nov 15.  [Abstract]

    Treatment with the AMDAR inhibitor (NBQX) and NMDAR inhibitor (D-AP5) effectively reduce the expression of NMDAR (NR1, NR2A/2B) and AMPAR (GluA1, GluA2) in PFC, respectively.

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    AMPA Receptor NMDA Receptor Kainate Receptor

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    DL-AP5 (2-APV) lithium is a competitive NMDA (N-methyl-D-aspartate) receptor antagonist. DL-AP5 lithium shows significantly antinociceptive activity. DL-AP5 lithium specifically blocks on channels in the rabbit retina[1][2][3].

    IC50 & Target

    NMDA Receptor

     

    体外研究
    (In Vitro)

    DL-AP5 (100 μM) partially prevents glutamate-induced increase in Arc/Arg3.1 protein levels[5].
    DL-AP5 decreases the NMDA-induced Arc/Arg3.1 upregulation[5].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    DL-AP5 lithium 相关抗体:
    体内研究
    (In Vivo)

    DL-AP5 (0-10 μg/rat, Intra-CA1) significantly decreases the effect of NMDA[3].
    DL-AP5 (0-10 nmol, Intracerebroventricular injection) causes a dose-dependent increase in food consumption[4].
    DL-AP5 (5 nmol, Intracerebroventricular injection) attenuates the decreased food consumption induced by the intracerebroventricular injection of ghrelin[4].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Male Wistar rats (180-230 g)[3]
    Dosage: 1, 3.2 and 10 μg/rat
    Administration: Injected into the intra-dorsal hippocampal (intra-CA1) immediately after shock administration, once
    Result: Significantly decreased the effect of NMDA (10-2 μg/rat, intra-CA1) with significant interaction.
    Animal Model: Broilers cockerels (3-h fooddeprived (FD3), n=8 for each group)[4]
    Dosage: 0, 2.5, 5, and 10 nmol; in a volume of 10 μL
    Administration: Intracerebroventricular injection
    Result: Caused a dose-dependent increase in food consumption which was significant for 5 and 10 nmol doses.
    Animal Model: Broilers cockerels (3-h fooddeprived (FD3), n=8 for each group)[4]
    Dosage: 5 nmol
    Administration: Intracerebroventricular injection, followed by ghrelin (0.6 nmol)
    Result: Attenuated the decreased food consumption induced by the intracerebroventricular injection of ghrelin.
    分子量

    203.06

    Formula

    C5H11LiNO5P
    CAS 号
    中文名称

    DL -2-氨基-5-磷戊酸锂盐
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    纯度 & 产品资料
    参考文献

    DL-AP5 lithium 相关分类

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    DL-AP5125229-62-12-APVDL-2-Amino-5-phosphonovaleric acidDL -2-氨基-5-磷戊酸锂盐iGluRIonotropic glutamate receptorsAntinociceptive activityTonic painGanglion cellsRetinaArc/Arg3.1Glutamate receptorInhibitorinhibitorinhibit

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