2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. iGluR
  4. DL-AP5

DL-AP5  (Synonyms: 2-APV; DL-2-Amino-5-phosphonovaleric acid)

目录号: HY-100714 纯度: ≥98.0%
COA 产品使用指南

摩尔计算器

DL-AP5 (2-APV) 是一种竞争性的 NMDA (N-methyl-D-aspartate) 受体拮抗剂。DL-AP5 表现出明显的镇痛活性。DL-AP5 可特异性阻断兔视网膜的通道。

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DL-AP5 Chemical Structure

DL-AP5 Chemical Structure

CAS No. : 76326-31-3

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规格 价格 是否有货 数量
10 mM * 1 mL in Water ￥957
In-stock
5 mg ￥870
In-stock
10 mg ￥1400
In-stock
25 mg ￥3000
In-stock
50 mg ￥5000
In-stock
100 mg   询价  
200 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of DL-AP5:

DL-AP5 相关抗体

Top Publications Citing Use of Products

查看 iGluR 亚型特异性产品:

查看所有亚型
AMPA Receptor NMDA Receptor Kainate Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DL-AP5 (2-APV) is a competitive NMDA (N-methyl-D-aspartate) receptor antagonist. DL-AP5 shows significantly antinociceptive activity. DL-AP5 specifically blocks on channels in the rabbit retina[1][2][3].

IC50 & Target

NMDA Receptor

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
Pyramidal neuron IC50
0.31 μM
Compound: L-AP5
sensitization of CA1 pyramidal neurons by 2 to depolarizations by L-AP4,L-AP5 and L-AP6 after exposure to quisqualic acid
sensitization of CA1 pyramidal neurons by 2 to depolarizations by L-AP4,L-AP5 and L-AP6 after exposure to quisqualic acid
[PMID: 7966155]
Pyramidal neuron IC50
2.2 μM
Compound: L-AP5
sensitization of CA1 pyramidal neurons by 2 to depolarizations by L-AP4, L-AP5 and L-AP6 after reversal with L-alpha-AA
sensitization of CA1 pyramidal neurons by 2 to depolarizations by L-AP4, L-AP5 and L-AP6 after reversal with L-alpha-AA
[PMID: 7966155]
Pyramidal neuron IC50
2.3 μM
Compound: L-AP5
sensitization of CA1 pyramidal neurons by 2 to depolarizations by L-AP4, L-AP5 and L-AP6 before exposure to quisqualic acid
sensitization of CA1 pyramidal neurons by 2 to depolarizations by L-AP4, L-AP5 and L-AP6 before exposure to quisqualic acid
[PMID: 7966155]
体外研究
(In Vitro)

DL-AP5 (100 μM) partially prevents glutamate-induced increase in Arc/Arg3.1 protein levels[5].
DL-AP5 decreases the NMDA-induced Arc/Arg3.1 upregulation[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

DL-AP5 相关抗体:
体内研究
(In Vivo)

DL-AP5 (0-10 μg/rat, Intra-CA1) significantly decreases the effect of NMDA[3].
DL-AP5 (0-10 nmol, Intracerebroventricular injection) causes a dose-dependent increase in food consumption[4].
DL-AP5 (5 nmol, Intracerebroventricular injection) attenuates the decreased food consumption induced by the intracerebroventricular injection of ghrelin[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats (180-230 g)[3]
Dosage: 1, 3.2 and 10 μg/rat
Administration: Injected into the intra-dorsal hippocampal (intra-CA1) immediately after shock administration, once
Result: Significantly decreased the effect of NMDA (10-2 μg/rat, intra-CA1) with significant interaction.
Animal Model: Broilers cockerels (3-h fooddeprived (FD3), n=8 for each group)[4]
Dosage: 0, 2.5, 5, and 10 nmol; in a volume of 10 μL
Administration: Intracerebroventricular injection
Result: Caused a dose-dependent increase in food consumption which was significant for 5 and 10 nmol doses.
Animal Model: Broilers cockerels (3-h fooddeprived (FD3), n=8 for each group)[4]
Dosage: 5 nmol
Administration: Intracerebroventricular injection, followed by ghrelin (0.6 nmol)
Result: Attenuated the decreased food consumption induced by the intracerebroventricular injection of ghrelin.
分子量

197.13

Formula

C5H12NO5P
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

H2O 中的溶解度 : 33.33 mg/mL (169.08 mM; 超声助溶 (<60°C))

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 5.0728 mL 25.3640 mL 50.7279 mL
5 mM 1.0146 mL 5.0728 mL 10.1456 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物实验：

以下溶解方案，请直接配制工作液。建议现用现配，在短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比； 如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。

  • 方案 一

    请依序添加每种溶剂： PBS

    Solubility: 50 mg/mL (253.64 mM); 澄清溶液; 超声助溶

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料

纯度: ≥98.0%

COA (282 KB) HNMR (236 KB) CNMR (287 KB) MS (71 KB)

产品使用指南 (1538 KB)
参考文献

DL-AP5 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 5.0728 mL 25.3640 mL 50.7279 mL 126.8199 mL
5 mM 1.0146 mL 5.0728 mL 10.1456 mL 25.3640 mL
10 mM 0.5073 mL 2.5364 mL 5.0728 mL 12.6820 mL
15 mM 0.3382 mL 1.6909 mL 3.3819 mL 8.4547 mL
20 mM 0.2536 mL 1.2682 mL 2.5364 mL 6.3410 mL
25 mM 0.2029 mL 1.0146 mL 2.0291 mL 5.0728 mL
30 mM 0.1691 mL 0.8455 mL 1.6909 mL 4.2273 mL
40 mM 0.1268 mL 0.6341 mL 1.2682 mL 3.1705 mL
50 mM 0.1015 mL 0.5073 mL 1.0146 mL 2.5364 mL
60 mM 0.0845 mL 0.4227 mL 0.8455 mL 2.1137 mL
80 mM 0.0634 mL 0.3170 mL 0.6341 mL 1.5852 mL
100 mM 0.0507 mL 0.2536 mL 0.5073 mL 1.2682 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DL-AP576326-31-32-APV DL-2-Amino-5-phosphonovaleric acidiGluRIonotropic glutamate receptorsAntinociceptive activityTonic painGanglion cellsRetinaArc/Arg3.1Glutamate receptorInhibitorinhibitorinhibit

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