2. 多肽产品
  3. 多肽及其衍生物
  4. DMP-728 free base

DMP-728 free base  (Synonyms: XL-118)

目录号: HY-167848
产品使用指南

摩尔计算器

DMP-728 free base (XL-118)是一种高度有效和选择性的GPIIb/IIIa拮抗剂，具有抗血小板和抗血栓的活性。DMP-728 free base在体外可以抑制ADP诱导的人类血小板聚集，IC50为46 nmol/L，并且能显著降低纤维蛋白原与人类血小板或纯化人GPIIb/IIIa受体的结合。DMP-728 free base在麻醉的杂种狗中表现出剂量依赖性的抗血小板作用，有效抑制ADP引发的血小板聚集并延长模板出血时间。

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Custom Peptide Synthesis

DMP-728 free base Chemical Structure

DMP-728 free base Chemical Structure

CAS No. : 153345-74-5

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DMP-728 free base 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DMP-728 free base (XL-118) is a highly potent and selective GPIIb/IIIa antagonist with antiplatelet and antithrombotic activities. DMP-728 free base can inhibit ADP-induced human platelet aggregation in vitro, with an IC50 of 46 nmol/L, and can significantly reduce the interaction between fibrinogen and human platelets or Binding of purified human GPIIb/IIIa receptors. DMP-728 free base exhibits dose-dependent antiplatelet effects in anesthetized mongrel dogs, effectively inhibiting ADP-induced platelet aggregation and prolonging template bleeding time[1].

分子量

560.60

Formula

C25H36N8O7
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

DMP-728 free base 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DMP-728153345-74-5XL-118DMP728DMP 728XL118XL 118OthersInhibitorinhibitorinhibit

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