2. Cell Cycle/DNA Damage
  3. DNA Alkylator/Crosslinker
  4. DNA crosslinker 4 dihydrochloride

DNA crosslinker 4 (dihydrochloride) 是一种有效的 DNA 小沟结合剂。DNA crosslinker 4 (dihydrochloride) 对癌细胞 NCI-H460、A2780 和 MCF-7 有一定的抑制活性。DNA crosslinker 4 (dihydrochloride) 可用于抗癌研究。

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DNA crosslinker 4 dihydrochloride Chemical Structure

DNA crosslinker 4 dihydrochloride Chemical Structure

CAS No. : 2761734-23-8

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DNA crosslinker 4 dihydrochloride 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DNA crosslinker 4 (dihydrochloride) is a potent DNA minor groove binder. DNA crosslinker 4 (dihydrochloride) has certain inhibitory activity against cancer cells NCI-H460, A2780 and MCF-7. DNA crosslinker 4 (dihydrochloride) can be used for researching anticancer[1].

IC50 & Target

IC50: 21 ± 1 μM in A2780 cells[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A2780 IC50
21 μM
Compound: 2
Cytotoxicity against human A2780 cells assessed as reduction in cell viability measured after 96 hrs by MTT assay
Cytotoxicity against human A2780 cells assessed as reduction in cell viability measured after 96 hrs by MTT assay
[PMID: 35300077]
体外研究
(In Vitro)

DNA crosslinker 4 (dihydrochloride) (compound 2) (100 μM; 48 h or 96 h) exhibits inhibitory activity against NCI-H460, A2780 and MCF-7[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

DNA crosslinker 4 dihydrochloride 相关抗体:

Cell Viability Assay

Cell Line: NCI-H460, A2780 and MCF-7[1]
Concentration: 100 μM
Incubation Time: 48 h (NCI-H460) and 96 h (A2780 and MCF-7)
Result: Exhibited inhibitory activity against NCI-H460, A2780 and MCF-7 with inhibition percentage of 34%, 59% and 22% at 100 μM; and showed an IC50 value of 21 ± 1 μM in A2780 cells.
分子量

415.32

Formula

C16H24Cl2N8O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

DNA crosslinker 4 dihydrochloride 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DNA crosslinker 42761734-23-8DNA crosslinker4DNA crosslinker-4DNA Alkylator/CrosslinkerAnticancerDNAMinor grooveNCI-H460A2780MCF-7Inhibitorinhibitorinhibit

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产品名称：
DNA crosslinker 4 dihydrochloride
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