2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. DU125530

DU125530 是一种有效的选择性 5-HT1A 受体 拮抗剂，对 5-HT1A、5-HT1B、5-HT1D、5-HT2A、5-HT2C、5-HT3 的 Ki 值分别为 0.7、890、1200、240、750、1100 nM。DU125530 具有抗抑郁作用。

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DU125530 Chemical Structure

DU125530 Chemical Structure

CAS No. : 161611-99-0

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规格 是否有货
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DU125530 相关抗体

Top Publications Citing Use of Products

查看 5-HT Receptor 亚型特异性产品:

查看所有亚型
5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor 5-HT Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DU125530 is a potent and selective5-HT1A receptor antagonist with Ki values of 0.7, 890, 1200, 240, 750, 1100 nM for 5-HT1A, 5-HT1B, 5-HT1D, 5-HT2A, 5-HT2C, 5-HT3, respectively. DU125530 shows antidepressant effects[1][2].

IC50 & Target[1]

5-HT1A Receptor

0.7 nM (Ki)

5-HT1B Receptor

890 nM (Ki)

5-HT1C Receptor

1200 nM (Ki)

5-HT2A Receptor

240 nM (Ki)

5-HT2C Receptor

750 nM (Ki)

5-HT3 Receptor

1100 nM (Ki)

体内研究
(In Vivo)

DU125530 (3 mg/kg; s.c.) 在野生型小鼠中的降低 8-OH-DPAT (HY-112061) 诱导的 5-HT 释放的减少[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: wild-type mice[2]
Dosage: 3 mg/kg
Administration: S.c.
Result: Prevented the reduction of 5-HT release induced by 0.5 mg·kg−1 s.c. 8-OH-DPAT in WT mice, alone had no effect on the extracellular 5-HT concentration in mPFC of wild-type mice (WT) nor in 5-HT1A receptor knock-out mice (KO).
Clinical Trial
分子量

491.99

Formula

C23H26ClN3O5S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

DU125530 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DU125530161611-99-0DU 125530DU-1255305-HT ReceptorSerotonin Receptor5-hydroxytryptamine Receptor5-HT releaseantidepressantmPFC8-OH-DPATInhibitorinhibitorinhibit

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产品名称：
DU125530
目录号：
HY-19283
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