2. Vitamin D Related/Nuclear Receptor Apoptosis
  3. Estrogen Receptor/ERR Apoptosis
  4. (E/Z)-Droloxifene

(E/Z)-Droloxifene  (Synonyms: (E/Z)-3-Hydroxytamoxifen)

目录号: HY-121149B
产品使用指南 技术支持

(E/Z)-Droloxifene 是 (E) -Droloxifene (一种选择性雌激素受体调节剂) 和 (Z) -Droloxifene 的混合物。(E) -Droloxifene 在兔子宫匀浆中结合雌激素受体 (ER)，IC50 值为 24 nM。(E) -Droloxifene 增加未成熟大鼠子宫重量，减少雌二醇引起的幼年大鼠子宫重量增加。(E) -Droloxifene 还能抑制 17β-雌二醇刺激的 MCF-7、ZR-75-1 和 T47D 人乳腺癌细胞的生长。(Z)-Droloxifene 与 ER 结合较弱，无雌激素活性或抗雌激素活性。

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(E/Z)-Droloxifene Chemical Structure

(E/Z)-Droloxifene Chemical Structure

CAS No. : 165813-01-4

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(E/Z)-Droloxifene 相关抗体

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Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

(E/Z)-Droloxifene is a mixture of (E)-droloxifene (a selective estrogen receptor modulator) and (Z)-droloxifene. (E)-Droloxifene binds to the estrogen receptor (ER) with an IC50 value of 24 nM in rabbit uterine homogenates. (E)-Droloxifene increases uterine weight in immature rats, and reduces estradiol-induced increases in uterine weight in juvenile rats. (E)-Droloxifene also inhibits 17β-estradiol-stimulated growth of MCF-7, ZR-75-1, and T47D human breast cancer cells. (Z)-Droloxifene binds weakly to ER and has no estrogenic or antiestrogenic activity[1][2][3][4].

分子量

387.51

Formula

C26H29NO2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

(E/Z)-Droloxifene 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

(E/Z)-Droloxifene165813-01-4(E/Z)-3-HydroxytamoxifenEstrogen Receptor/ERRApoptosis(E)-droloxifene(Z)-droloxifeneERrabbit uterine homogenatescancer cellsInhibitorinhibitorinhibit

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