2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. (E/Z)-NSAH

(E/Z)-NSAH 是 NSAH (HY-114503) 的异构体。NSAH 是可逆的、竞争性的非核苷类的核苷酸还原酶 (RR 抑制剂，在 cell-free 和 cell-bases 背景下的 IC50 分别为 32 μM 和 ~250 nM。

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(E/Z)-NSAH Chemical Structure

(E/Z)-NSAH Chemical Structure

CAS No. : 54009-54-0

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规格 价格 是否有货 数量
5 mg ￥711
1 - 2 周
10 mg ￥1066
1 - 2 周
25 mg ￥1759
1 - 2 周
50 mg ￥2639
1 - 2 周
100 mg ￥3958
1 - 2 周
250 mg 现货 1 - 2 周
500 mg   询价  
1 g   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of (E/Z)-NSAH:

(E/Z)-NSAH 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

(E/Z)-NSAH is an isoform of NSAH (HY-114503), which is reversible and competitive nonnucleoside ribonucleotide reductase (RR) inhibitor, with cell-free IC50 of 32 μM and cell-based IC50 of ~250 nM, respectively[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HCT-116 IC50
225 nM
Compound: E-3a
Growth inhibition of human HCT116 cells after 72 hrs by Hoechst 33258 dye based fluorescence assay
Growth inhibition of human HCT116 cells after 72 hrs by Hoechst 33258 dye based fluorescence assay
[PMID: 29253340]
MDA-MB-231 IC50
0.347 μM
Compound: E-3a
Growth inhibition of human MDA-MB-231 cells treated with 4 pmol RRM1 siRNA after 5 days by Hoechst 33258 dye based fluorescence assay
Growth inhibition of human MDA-MB-231 cells treated with 4 pmol RRM1 siRNA after 5 days by Hoechst 33258 dye based fluorescence assay
[PMID: 29253340]
MDA-MB-231 IC50
1.43 μM
Compound: E-3a
Growth inhibition of human MDA-MB-231 cells treated with 2 pmol RRM1 siRNA at 0.1 to 10 uM after 5 days by Hoechst 33258 dye based fluorescence assay
Growth inhibition of human MDA-MB-231 cells treated with 2 pmol RRM1 siRNA at 0.1 to 10 uM after 5 days by Hoechst 33258 dye based fluorescence assay
[PMID: 29253340]
MDA-MB-231 IC50
1.49 μM
Compound: E-3a
Growth inhibition of human MDA-MB-231 cells after 5 days by Hoechst 33258 dye based fluorescence assay
Growth inhibition of human MDA-MB-231 cells after 5 days by Hoechst 33258 dye based fluorescence assay
[PMID: 29253340]
MDA-MB-231 IC50
1.94 μM
Compound: E-3a
Growth inhibition of human MDA-MB-231 cells treated with 4 pmol scrambled siRNA after 5 days by Hoechst 33258 dye based fluorescence assay
Growth inhibition of human MDA-MB-231 cells treated with 4 pmol scrambled siRNA after 5 days by Hoechst 33258 dye based fluorescence assay
[PMID: 29253340]
MDA-MB-231 IC50
300 nM
Compound: E-3a
Growth inhibition of human MDA-MB-231 cells after 72 hrs by Hoechst 33258 dye based fluorescence assay
Growth inhibition of human MDA-MB-231 cells after 72 hrs by Hoechst 33258 dye based fluorescence assay
[PMID: 29253340]
分子量

306.32

Formula

C18H14N2O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

(E/Z)-NSAH 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(E/Z)-NSAH54009-54-0DNA/RNA SynthesisMDA-231HCT116Panc1S-phaseInhibitorinhibitorinhibit

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Inquiry Information

产品名称：
(E/Z)-NSAH
目录号：
HY-114503A
需求量：

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