2. PROTAC
  3. Ligands for E3 Ligase
  4. E3 ligase Ligand PG

E3 ligase Ligand PG 是一种可用于募集 CRBN 蛋白的 E3 连接酶配体 (E3 ligase ligand)。E3 ligase Ligand PG 与 CRBN 表现出强效结合活性（IC50 为 2.191 μM）。E3 ligase Ligand PG 可通过 linker 与 BMS-202（HY-19745）连接形成 PROTAC，PROTAC PD-L1 degrader-1 (HY-163757)。

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E3 ligase Ligand PG Chemical Structure

E3 ligase Ligand PG Chemical Structure

CAS No. : 14149-34-9

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E3 ligase Ligand PG 相关抗体

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von Hippel-Lindau (VHL) MDM2 Cereblon IAP

  • 生物活性

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生物活性

E3 ligase Ligand PG is a E3 ligase ligand that can be used in the recruitment of CRBN protein. E3 ligase Ligand PG exhibits potent binding activity with CRBN (IC50 of 2.191 μM). E3 ligase Ligand PG can be connected to the BMS-202 (HY-19745) by a linker to form PROTAC, PROTAC PD-L1 degrader-1 (HY-163757)[1].

IC50 & Target[1]

Cereblon

2.191 μM (IC50)

分子量

189.21

Formula

C11H11NO2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

E3 ligase Ligand PG 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

E3 ligase Ligand PG14149-34-9Ligands for E3 LigaseE3 ligase-recruiting MoietyE3 ligase ligandCRBNBMS-202PD-L1Inhibitorinhibitorinhibit

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