2. Membrane Transporter/Ion Channel
  3. Calmodulin
  4. E6 Berbamine

E6 Berbamine  (Synonyms: Berbamine p-nitrobenzoate)

目录号: HY-120997
产品使用指南

摩尔计算器

E6 Berbamine (Berbamine p-nitrobenzoate) 是一种有效的钙调蛋白（CaM）拮抗剂。E6 Berbamine 可抑制钙调蛋白 (CaM) 依赖性肌球蛋白轻链激酶 (MLCK) 的活性，Ki 为 0.95 μM。E6 Berbamine 还具有抗白血病活性，在 K562 细胞中的 IC50 为 2.13 μM。

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E6 Berbamine Chemical Structure

E6 Berbamine Chemical Structure

CAS No. : 114784-59-7

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E6 Berbamine 相关抗体

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  • 生物活性

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生物活性

E6 Berbamine (Berbamine p-nitrobenzoate) is a potent calmodulin (CaM) antagonist. E6 Berbamine inhibits the activity of calmodulin (CaM)-dependent myosin light chain kinase (MLCK), with a Ki of 0.95 μM[1]. E6 Berbamine also shows anti-leukemia activities, with an IC50 of 2.13 μM in K562 cells[2].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
K562 IC50
2.13 μM
Compound: 3n
Cytotoxicity against human imatinib-resistant K562 leukemia cells expressing p210Bcr/Abl and MDR1 at 48 hrs by MTT assay
Cytotoxicity against human imatinib-resistant K562 leukemia cells expressing p210Bcr/Abl and MDR1 at 48 hrs by MTT assay
[PMID: 19285759]
分子量

757.83

Formula

C44H43N3O9
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

E6 Berbamine 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

E6 Berbamine114784-59-7Berbamine p-nitrobenzoateCalmodulinCaMCalcium-modulated proteincalmodulin antagonistMLCKanti-leukemia activitiesInhibitorinhibitorinhibit

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