2. Cell Cycle/DNA Damage Cytoskeleton
  3. Microtubule/Tubulin
  4. E7130

E7130 是一种微管 (microtubule) 抑制剂，通过抑制癌症相关成纤维细胞和提高肿瘤脉管系统重塑来改善肿瘤微环境。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

E7130 Chemical Structure

E7130 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

E7130 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

E7130 is a microtubule inhibitor, which ameliorates the tumor microenvironment through suppression of cancer-associated fibroblasts (CAF) and promotion of tumor vasculature remodeling[1].

体外研究
(In Vitro)

E7130 抑制微管动力学，并在癌细胞 KPL-4，OSC-19，FaDu 和 HSC-2 中显示抗增殖活性，IC50 值分别为 0.01-0.1 nM[1]。
E7130 (0.15 nM) 通过破坏微管网络的形成抑制 TGF-β 诱导的肌成纤维细胞转化，使 PI3K/AKT/mTOR 通路失活[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

E7130 相关抗体:

Immunofluorescence[1]

Cell Line: BJ cells
Concentration: 0.15 nM
Incubation Time: 48 h
Result: Inhibited TGF-β-induced α-SMA expression in BJ cells without growth inhibitory activity.

Western Blot Analysis[1]

Cell Line: BJ cells
Concentration: 0.15 nM
Incubation Time: 48 h
Result: Decreased levels of pAKT and pS6.
体内研究
(In Vivo)

E7130 (45-180 μg/kg，静脉注射) 增加肿瘤内微血管密度 (MVD)，从而增加 cetuximab (CTX) 向肿瘤的递送，导致 HSC-2 SCCHN 异种移植 BALB/c 小鼠中的肿瘤消退[1]。
E7130 (45-180 μg/kg，静脉注射) 减少 α-SMA 阳性 CAF，E7130-CTX 组合可调节 FaDu SCCHN 异种移植 BALB/c 小鼠中成纤维细胞的表型[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: FaDu SCCHN xenograft BALB/c mice[1]
Dosage: 45-180 μg/kg
Administration: i.v.
Result: Reduced the α-SMA-positive CAFs, modulated the phenotypes of the fibroblasts with combination of CTX.
Animal Model: HSC-2 SCCHN xenograft BALB/c mice[1]
Dosage: 90 μg/kg
Administration: i.v.
Result: Increased MVD, inhibited tumor growth.
Increased survival rate with combination of CTX.
分子量

1066.28

Formula

C58H83NO17
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

E7130 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

E7130E 7130E-7130Microtubule/Tubulincancer-associated fibroblastCAFHSC-2FaDuInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
E7130
目录号：
HY-161248
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z