2. NF-κB
  3. NF-κB
  4. Echinulin

Echinulin  (Synonyms: Echinuline)

目录号: HY-N3796 纯度: 98.63%
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Echinulin (Echinuline) 是一种带有三苯甲基化吲哚部分的环状二肽。 Echinulin 有助于激活 T 细胞亚群，从而导致 NF-κB 活化。Echinulin 通过 NF-κB 途径发挥其免疫作用。Echinulin 具有作为免疫抑制剂的潜力。

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Echinulin Chemical Structure

Echinulin Chemical Structure

CAS No. : 1859-87-6

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规格 价格 是否有货 数量
1 mg ￥2800
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Echinulin 相关抗体

Top Publications Citing Use of Products

查看 NF-κB 亚型特异性产品:

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Echinulin (Echinuline) is a cyclic dipeptide carrying a triprenylated indole moiety. Echinulin contributes to the activation of T cell subsets, which leads to NF-κB activation.Echinulin exerts its immune roles by the NF-κB pathway.Echinulin has the potential to serve as a immunotherapeutic agent[1].

IC50 & Target[1]

NF-κB

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
B16-4A5 IC50
68 μM
Compound: 2
Inhibition of melanogenesis in theophylline-stimulated mouse B16-4A5 cells assessed as reduction in melanin level incubated for 72 hrs
Inhibition of melanogenesis in theophylline-stimulated mouse B16-4A5 cells assessed as reduction in melanin level incubated for 72 hrs
[PMID: 27641468]
MDCK CC50
> 200 μM
Compound: 22
Cytotoxicity against MDCK cells assessed as cell growth after 40 hrs by CellTiter-Glo assay
Cytotoxicity against MDCK cells assessed as cell growth after 40 hrs by CellTiter-Glo assay
[PMID: 25681711]
分子量

461.64

Formula

C29H39N3O2
CAS 号
性状

固体

颜色

White to off-white

结构分类
初始来源

Aspergillus chevalieri
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料
参考文献

Echinulin 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Echinulin1859-87-6EchinulineNF-κBNuclear factor-κBNuclear factor-kappaBcyclic dipeptidetriprenylated indole moietyT cell subsetsimmunotherapeutic agentInhibitorinhibitorinhibit

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