2. Anti-infection
  3. Parasite
  4. ELQ-598

ELQ-598 作为一种前体药物，它通过口服形式在体内转变为活性药物 ELQ-596。ELQ-598 显示出强效的寄生虫生长抑制能力 (IC50= 37 nM)，以及对人类细胞的低毒性 (IC50= 19 μM)。ELQ-598 能够用于巴贝斯虫病的研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

我们将采用定制合成服务的方式为您快速提供所需产品和技术服务

ELQ-598 Chemical Structure

ELQ-598 Chemical Structure

CAS No. : 3023709-99-8

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

ELQ-598 相关抗体

Top Publications Citing Use of Products

查看 Parasite 亚型特异性产品:

查看所有亚型
Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ELQ-598, as a prodrug, is converted into the active drug ELQ-596 upon oral administration. ELQ-598 demonstrates potent parasitic growth inhibition capabilities (IC50= 37 nM). ELQ-598 also shows low toxicity towards human cells (IC50= 19 μM). ELQ-598 can be used for research into babesiosis[1].

体内研究
(In Vivo)

ELQ-598 (10 mg/kg; p.o.; 感染后第三天到第七天) 完全消除了 C3H 小鼠的邓肯芽孢杆菌感染[1]。
ELQ-598 (10 mg/kg; p.o.; 感染后第三天到第七天) 可有效消除小鼠的微小芽孢杆菌感染[1]。
ELQ-598 (10 mg/kg; p.o.; 感染后第三天到第七天) 联合 atovaquone (HY-13832) 可以消除 C3H/HeJ 小鼠中的邓肯芽孢杆菌感染和 SCID 小鼠的微小芽孢杆菌感染[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C3H mice genetically prone to B. duncani infection[1]
Dosage: 10mg/kg
Administration: p.o.; daily DPI 3-7
Result: Resulted in a complete elimination of the parasites. Mice survived for the duration of the study with no recurrence of parasitemia observed.
Animal Model: C3H/HeJ mice for B. duncani infection, and SCID mice for B. microti infection[1]
Dosage: 10mg/kg with 10mg/kg atovaquone,
Administration: p.o.; daily DPI 3-7
Result: All mice survived without any recurrence of parasitemia.
A potent synergistic or additive effect of the drug combination in eradicating the lethal infection.This combination strategy offers enhanced efficacy compared to the use of either compound alone.
分子量

561.93

Formula

C28H23ClF3NO6
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ELQ-598 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ELQ-5983023709-99-8ELQ598ELQ 598ParasiteAntiparasiticProdrug of ELQ-596BabesiosisMitochondrial Cytochrome bc1 InhibitorC3H miceSCID miceInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
ELQ-598
目录号：
HY-163483
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z