Empasiprubart  (Synonyms: ARGX-117)

Empasiprubar (ARGX-117) is a humanized inhibitory monoclonal antibody targeting complement C2. Empasiprubar binds to the Sushi-2 domain of C2, preventing the formation of C3 pre convertase and inhibiting the activation of classical and lectin pathways upstream of C3 activation. Empasiprubar can prevent complement mediated autoimmune hemolytic anemia and antibody mediated organ transplant rejection. Empasiprubar can prevent neuroglial lymphoconjunctival injury in GM1 antibody mediated mouse models^[1][2].

Human IgG1 kappa

Human IgG1 kappa, Isotype Control

Humanized

Empasiprubart 在体外模型中预防补体介导的自身免疫性溶血性贫血和抗体介导的器官移植排斥反应^[1]。
Empasiprubart 在诱导多能干细胞 (iPSC) 衍生的运动神经元 (MN) 模型中可以抑制抗 GM1 抗体与 MNs 结合诱导的 C4 下游补体激活^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Empasiprubart (0.5-30 mg/kg; 每天 1 次; 60 天; 静脉注射) 在食蟹猴中靶向抑制经典通路 (CP) 和凝集素通路 (LP)，不影响替代通路 (AP)^[1]。
Empasiprubart (200 mg/kg; 1 次; 静脉注射) 可预防 GM1 抗体介导的小鼠模型中的神经胶质淋巴结膜损伤^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

2579031-19-7

液体

Colorless to light yellow

Shipping with dry ice.

Please store the product under the recommended conditions in the Certificate of Analysis.

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  Human IgG1 kappa

• [1]. Van de Walle I, et al. ARGX-117, a therapeutic complement inhibiting antibody targeting C2. J Allergy Clin Immunol. 2021 Apr;147(4):1420-1429.e7.  [Content Brief]

  [2]. Campbell CI, et al. Complement inhibition prevents glial nodal membrane injury in a GM1 antibody-mediated mouse model. Brain Commun. 2022 Nov 23;4(6):fcac306.  [Content Brief]

  [3]. Budding K, et al. Anti-C2 Antibody ARGX-117 Inhibits Complement in a Disease Model for Multifocal Motor Neuropathy. Neurol Neuroimmunol Neuroinflamm. 2021 Nov 10;9(1):e1107.  [Content Brief]