2. Apoptosis Metabolic Enzyme/Protease
  3. Apoptosis Endogenous Metabolite
  4. Enterolactone

Enterolactone 是一种生物活性酚类代谢物，被称为哺乳动物木酚素，来源于膳食木酚素。Enterolactone 具有雌激素特性和抗乳腺癌活性。Enterolactone 是人乳腺癌细胞系的放射增敏剂，通过受损的 DNA修复和增加的细胞凋亡 (apoptosis)。

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Enterolactone Chemical Structure

Enterolactone Chemical Structure

CAS No. : 78473-71-9

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规格 价格 是否有货 数量
1 mg ￥1260
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Customer Review

Other Forms of Enterolactone:

Enterolactone 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Enterolactone is a bioactive phenolic metabolite known as a mammalian lignan derived from dietary lignans. Enterolactone has estrogenic properties and anti-breast cancer activity[1]. Enterolactone is a radiosensitizer for human breast cancer cell lines through impaired DNA repair and increased apoptosis[2].

体外研究
(In Vitro)

Enterolactone (25-75 μM; 48 hours) arrests the growth of MDA-MB-231 breast cancer cells in the ‘S’ phase[1]
Enterolactone (25-75 μM; 15 hours) triggers apoptosis in MDA-MB-231 breast cancer cells via caspase-3 activation[1].
Enterolactone inhibits TGF-β-induced migration of MDA-MB-231 breast cancer cells. Enterolactone inhibits TGF-β-induced invasion of MDA-MB-231 breast cancer cells through ECM. Enterolactone inhibits the TGF-β-induced EMT program in MDA-MB-231 breast cancer cells. Enterolactone reduces the formation of actin stress fibers by inhibiting the expression of CD44 and MAPK-p38. Enterolactone inhibits the ERK/NF-κB/Snail signaling pathway to revert TGF-β-induced EMT in MDA-MB-231 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Enterolactone 相关抗体:

Cell Viability Assay[1]

Cell Line: MDA-MB-231 cells
Concentration: 25, 50, 75 μM
Incubation Time: 48 hours
Result: There was a non-significant increase (~24%) in the S phase population following treatment with 25 μM EL, whereas there were significant increases (~34% and ~39%) following treatment with 50 and 75 μM EL, respectively.
分子量

298.33

Formula

C18H18O4
CAS 号
性状

固体

颜色

White to off-white

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 30 mg/mL (100.56 mM; 超声加热助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.3520 mL 16.7600 mL 33.5199 mL
5 mM 0.6704 mL 3.3520 mL 6.7040 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: ≥99.0%

COA (295 KB)

产品使用指南 (1538 KB)
参考文献

Enterolactone 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.3520 mL 16.7600 mL 33.5199 mL 83.7998 mL
5 mM 0.6704 mL 3.3520 mL 6.7040 mL 16.7600 mL
10 mM 0.3352 mL 1.6760 mL 3.3520 mL 8.3800 mL
15 mM 0.2235 mL 1.1173 mL 2.2347 mL 5.5867 mL
20 mM 0.1676 mL 0.8380 mL 1.6760 mL 4.1900 mL
25 mM 0.1341 mL 0.6704 mL 1.3408 mL 3.3520 mL
30 mM 0.1117 mL 0.5587 mL 1.1173 mL 2.7933 mL
40 mM 0.0838 mL 0.4190 mL 0.8380 mL 2.0950 mL
50 mM 0.0670 mL 0.3352 mL 0.6704 mL 1.6760 mL
60 mM 0.0559 mL 0.2793 mL 0.5587 mL 1.3967 mL
80 mM 0.0419 mL 0.2095 mL 0.4190 mL 1.0475 mL
100 mM 0.0335 mL 0.1676 mL 0.3352 mL 0.8380 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Enterolactone78473-71-9ApoptosisEndogenous Metabolitetriplenegativebreastcancer,celllineMDA-MB-231epithelialmesenchymaltransitioninvasionInhibitorinhibitorinhibit

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产品名称：
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目录号：
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