2. Vitamin D Related/Nuclear Receptor
  3. Estrogen Receptor/ERR
  4. ERα degrader 5

ERα degrader 5 (Compound 40) 是一种选择性的、具有口服活性的雌激素受体 (estrogen receptor (ER)) 降解剂，对 ERα 的 EC50 值为 1.1 nM。ERα degrader 5 在体内表现出抗肿瘤活性。

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ERα degrader 5 Chemical Structure

ERα degrader 5 Chemical Structure

CAS No. : 2941268-96-6

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ERα degrader 5 相关抗体

Top Publications Citing Use of Products

查看 Estrogen Receptor/ERR 亚型特异性产品:

查看所有亚型
Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ERα degrader 5 (Compound 40) is a selective, orally bioavailable estrogen receptor (ER) degrader (SERD) with an EC50 of 1.1 nM against ERα. ERα degrader 5 shows antitumor effect in vivo[1].

IC50 & Target

ERα

1.1 nM (EC50)

ERα

0.9 nM (IC50)

ERβ

2.3 nM (IC50)

体外研究
(In Vitro)

ERα degrader 5 (Compound 40) shows antiproliferative activity with an IC50 of 1.0 nM against MCF-7[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ERα degrader 5 相关抗体:
分子量

555.59

Formula

C29H25F4N3O2S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ERα degrader 5 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ERα degrader 52941268-96-6ERα degrader5ERα degrader-5Estrogen Receptor/ERRMCF-7ERα+ breast cancerselectiveorally bioavailableInhibitorinhibitorinhibit

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产品名称：
ERα degrader 5
目录号：
HY-146267
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