1. Metabolic Enzyme/Protease
  2. Renin
  3. ES 6864

ES 6864 是竞争性的,口服有效的人肾素 (human renin) 抑制剂,IC50 为 6.9 nM,Ki 为 7.3 nM。ES 6864 具有高度的物种特异性和酶特异性。ES 6864 在大鼠组织匀浆中表现出代谢稳定性。ES 6864 在大鼠和钠耗竭的清醒狨猴中,发挥降血压的作用。

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ES 6864 Chemical Structure

ES 6864 Chemical Structure

CAS No. : 116326-39-7

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ES 6864 is an orally active, competitive inhibitor for human renin, with an IC50 of 6.9 nM and a Ki of 7.3 nM. ES 6864 exhibits high species-specific and enzyme-specific properties. ES 6864 exhibits metabolic stability in rat tissue homogenates. ES 6864 reduces blood pressure in rats and sodium-depleted awake marmosets[1].

IC50 & Target

IC50: 6.9 nM (human renin)

分子量

791.01

Formula

C42H58N6O7S

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
ES 6864
目录号:
HY-125625
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