2. Metabolic Enzyme/Protease Others
  3. ANGPTL Others
  4. Evinacumab

Evinacumab  (Synonyms: 依维苏单抗; REGN1500)

目录号: HY-P99194 纯度: 98.98%
COA

摩尔计算器

Evinacumab (REGN1500) 是一种人源抗 ANGPTL3 (血管生成素样蛋白 3) 单克隆抗体 (IgG4 类抗体)。Evinacumab 可通过阻断 ANGPTL3 来降低血脂异常小鼠的血浆脂质。Evinacumab 可用于同型家族性高胆固醇血症 (HoFH)、难治性高胆固醇血症 (包括家族性和非家族性) 和严重高甘油三酯血症的研究。

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CAS No. : 1446419-85-7

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规格 价格 是否有货 数量
1 mg ￥4500
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Evinacumab 相关抗体

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ANGPTL3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Evinacumab (REGN1500) is a human anti-ANGPTL3 (angiopoietin-like protein 3) monoclonal antibody (IgG4 class antibody). Evinacumab reduces plasma lipids in dyslipidemic mice by blocking ANGPTL3. Evinacumab can be used in studies of homozygous familial hypercholesterolaemia (HoFH), refractory hypercholesterolaemia (both familial and non-familial) and severe hypertriglyceridaemia[1].

同型

Human IgG4 kappa
推荐同型对照抗体
种属

Human
IC50 & Target

ANGPTL3[1].
体内研究
(In Vivo)

Evinacumab (REGN1500) (10 mg/kg; s.c.; single) lowers serum TGs in normolipidemic C57Bl/6 mice and increases postheparin plasma LPL activity[1].
Evinacumab (25 mg/kg; s.c.; once weekly for 8 weeks) lowers serum TG and cholesterol levels in dyslipidemic C57Bl/6 mice[1].
Evinacumab (10 mg/kg; s.c.; single) lowers serum HDL-C by an EL-dependent mechanism in Lipg-/- mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57Bl/6 mice (8-week-old)[1].
Dosage: 10 mg/kg
Administration: Subcutaneous injection, single.
Result: Caused a rapid reduction in TG levels with the maximal mean level of serum TG 55% lower than control group, and reduced 26% levels of TC.
Significantly reduced VLDL-TG, VLDL-cholesterol, and HDL-C levels.
Increased postheparin plasma LPL and improved lipid tolerance.
Animal Model: Male C57Bl/6 mice (8-week-old; on a high-fat high-cholesterol diet)[1].
Dosage: 25 mg/kg
Administration: Subcutaneous injection, once weekly for 8 weeks.
Result: Led to a marked and sustained reduction in circulating TG levels (up to 53%).
Significantly reduced levels of TC (up to 35%) and LDL-C (up to 45%).
Animal Model: Lipg-/- mice[1].
Dosage: 10 mg/kg
Administration: Subcutaneous injection, single.
Result: Blocked the inhibitory action of ANGPTL3 on EL with an IC50 value of 96 nM.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

依维苏单抗
运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG4 kappa
纯度 & 产品资料
参考文献

Evinacumab 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Evinacumab1446419-85-7REGN1500依维苏单抗REGN 1500REGN-1500ANGPTLOthersAngiopoietin-like proteinIgG4HoFHrefractory hypercholesterolaemiasevere hypertriglyceridaemiaplasma lipidsInhibitorinhibitorinhibit

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