Ezabenlimab  (Synonyms: 埃本利单抗; BI-754091)

Ezabenlimab (BI-754091) is an anti-PD-1 mAb with binding constant K_d value of 6 nM (CHO cells). Ezabenlimab blocks the interaction of PD-1 with PD-L1 and PD-L2. Ezabenlimab increases interferon-γ secretion in T cells, and inhibits tumor growth in vivo^[1].

Human IgG4 kappa

Human IgG4 (S228P) kappa, Isotype Control

Humanized

PD-1/PD-L1, PD-1/PD-L2, IFN-γ^[1]

Ezabenlimab 抑制 CHO 细胞中 PD-1 与 PD-L1 和 PD-L2 的相互作用，IC₉₀ 分别为 4.14 nM 和 3.98 nM；抑制食蟹动物PD-1与PD-L1和PD-L2的相互作用，IC₉₀ 分别为 5.61 nM 和 7.54 nM^[1]。
Ezabenlimab 增加原发性人抗原经历的 CD3 阳性 T 细胞中 IFN-γ 的分泌，EC₅₀ 值为 0.9 nM^[1]。
Ezabenlimab (200 nM) 与 BI 754111 有协同作用，导致 IFN-γ 分泌的进一步增加^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Ezabenlimab (0.3-30 mg/kg; 腹腔注射; 单次或每周 2 次或每 3 周一次) 在 hPD-1 敲入小鼠模型中抑制肿瘤进展，并显示出相当的抗肿瘤活性^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

2249882-54-8

液体

Colorless to light yellow

埃本利单抗

Shipping with dry ice.

Please store the product under the recommended conditions in the Certificate of Analysis.

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  Human IgG4 kappa

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  Immobilized Human PD-1 Protein (ECD, His Tag) can bind Ezabenlimab. The EC₅₀ for this effect is 3.34 ng/mL.

• [1]. Zettl M, et al. Combination of two novel blocking antibodies, anti-PD-1 antibody ezabenlimab (BI 754091) and anti-LAG-3 antibody BI 754111, leads to increased immune cell responses. Oncoimmunology. 2022 Jun 16;11(1):2080328.  [Content Brief]