2. Anti-infection Metabolic Enzyme/Protease
  3. HCV Protease
  4. Faldaprevir

Faldaprevir  (Synonyms: BI 201335)

目录号: HY-15256 纯度: 98.58%
COA 产品使用指南 技术支持

Faldaprevir (BI 201335) 是一种对丙型肝炎病毒 (HCV) 1a 和 1b 基因型的 NS3/4A 蛋白酶的口服有效的选择性非共价抑制剂，其 Ki 值分别为 2.6 和 2.0 nM。Faldaprevir 抑制 HCV RNA 复制，其 EC50 分别为 6.5 和 3.1 nM。Faldaprevir 对慢性 HCV 感染具有强大的抗病毒活性。

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Faldaprevir Chemical Structure

Faldaprevir Chemical Structure

CAS No. : 801283-95-4

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规格 价格 是否有货 数量
1 mg ￥3400
In-stock
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Customer Review

Other Forms of Faldaprevir:

Faldaprevir 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Faldaprevir (BI 201335) is a potent, orally active and selective noncovalent inhibitor of NS3/4A protease of HCV (hepatitis C virus) genotypes 1a and 1b, with Ki values of 2.6 and 2.0 nM, respectively. Faldaprevir inhibits HCV RNA replication, with EC50 values of 6.5 and 3.1 nM, respectively. Faldaprevir has potent antiviral activity against chronic HCV infection[1][2].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
Huh-7 EC50
3.1 nM
Compound: BI 201335
Antiviral activity against HCV 1b infected in Huh7 cells assessed as inhibition of viral replication after 72 hrs by RT-PCR
Antiviral activity against HCV 1b infected in Huh7 cells assessed as inhibition of viral replication after 72 hrs by RT-PCR
[PMID: 20823284]
Huh-7 CC50
30000 nM
Compound: BI 201335
Cytotoxicity activity against human HuH7 cells by MTT assay
Cytotoxicity activity against human HuH7 cells by MTT assay
[PMID: 20823284]
Huh-7 EC50
43 nM
Compound: BI 201335
Antiviral activity against HCV 2a infected in Huh7 cells assessed as inhibition of viral replication after 72 hrs by RT-PCR
Antiviral activity against HCV 2a infected in Huh7 cells assessed as inhibition of viral replication after 72 hrs by RT-PCR
[PMID: 20823284]
Huh-7 EC50
50 nM
Compound: BI 201335
Antiviral activity against HCV 2a clone JFH1 infected in Huh7 cells assessed as inhibition of viral replication after 72 hrs by RT-PCR
Antiviral activity against HCV 2a clone JFH1 infected in Huh7 cells assessed as inhibition of viral replication after 72 hrs by RT-PCR
[PMID: 20823284]
Huh-7 EC50
6.5 nM
Compound: BI 201335
Antiviral activity against HCV 1a infected in Huh7 cells assessed as inhibition of viral replication after 72 hrs by RT-PCR
Antiviral activity against HCV 1a infected in Huh7 cells assessed as inhibition of viral replication after 72 hrs by RT-PCR
[PMID: 20823284]
Huh-7 EC50
6.5 nM
Compound: BI201335
Antiviral activity against Hepatitis C virus genotype 1b infected in human HuH7 cells by subgenomic replicon-based luciferase assay
Antiviral activity against Hepatitis C virus genotype 1b infected in human HuH7 cells by subgenomic replicon-based luciferase assay
[PMID: 24900813]
Clinical Trial
分子量

869.82

Formula

C40H49BrN6O9S
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 2 mg/mL (2.30 mM; 超声加热助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.1497 mL 5.7483 mL 11.4966 mL
5 mM --- --- ---
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Faldaprevir 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.1497 mL 5.7483 mL 11.4966 mL 28.7416 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Faldaprevir801283-95-4BI 201335BI201335BI-201335HCV ProteaseHepatitis C virus (HCV)Orally activeSelectiveNoncovalentAntiviral activityProteaseInhibitorinhibitorinhibit

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