2. Apoptosis Autophagy Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. Apoptosis Autophagy Reactive Oxygen Species
  4. Fascaplysin

Fascaplysin 是一种抗微生物和细胞毒性的红色素，可来自海洋海绵 Fascaplysinopsis sp.。Fascaplysin 是以吲哚为原料，经7步合成的(得率 65%)。Fascaplysin 可诱导人白血病 HL-60 细胞凋亡和自噬。Fascaplysin 具有抗肿瘤活性。

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Fascaplysin Chemical Structure

Fascaplysin Chemical Structure

CAS No. : 114719-57-2

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规格 价格 是否有货 数量
5 mg ￥4086
3 - 4 周
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Fascaplysin 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Fascaplysin is an antimicrobial and cytotoxic red pigment, that can come from the marine sponge (Fascaplysinopsis sp.). Fascaplysin has been synthesized in seven steps from indole (65% yield). Fascaplysin can induces apoptosis and autophagy in human leukemia HL-60 cells. Fascaplysin shows anti-tumor activity[1][2].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
0.69 μM
Compound: 2
Growth inhibition of p53+, pRb+ human A549 cells after 48 hrs by MTT assay
Growth inhibition of p53+, pRb+ human A549 cells after 48 hrs by MTT assay
[PMID: 25368960]
Calu-1 IC50
1.3 μM
Compound: 2
Growth inhibition of p53 null, pRb+ human Calu1 cells after 48 hrs by MTT assay
Growth inhibition of p53 null, pRb+ human Calu1 cells after 48 hrs by MTT assay
[PMID: 25368960]
LS174T IC50
0.88 μM
Compound: 2
Growth inhibition of p53+, pRb+ human LS 174T cells after 48 hrs by MTT assay
Growth inhibition of p53+, pRb+ human LS 174T cells after 48 hrs by MTT assay
[PMID: 25368960]
PC-3 IC50
0.92 μM
Compound: 2
Growth inhibition of p53 null,pRb+ human PC3 cells after 48 hrs by MTT assay
Growth inhibition of p53 null,pRb+ human PC3 cells after 48 hrs by MTT assay
[PMID: 25368960]
Sf9 IC50
0.35 μM
Compound: Fascaplysin
Inhibition of CDK4/Cyclin D (unknown origin) expressed in baculovirus infected insect Sf9 cells using human pRB as substrate in presence of [gamma-32P]ATP
Inhibition of CDK4/Cyclin D (unknown origin) expressed in baculovirus infected insect Sf9 cells using human pRB as substrate in presence of [gamma-32P]ATP
[PMID: 26741853]
Sf9 IC50
0.55 μM
Compound: 4
Inhibition of human CDK4/ Cyclin D1 catalytic subunit expressed in Sf9 insect cells assessed as GST-RB152 fusion protein phosphorylation-associated depletion in ATP level by luminescence assay
Inhibition of human CDK4/ Cyclin D1 catalytic subunit expressed in Sf9 insect cells assessed as GST-RB152 fusion protein phosphorylation-associated depletion in ATP level by luminescence assay
[PMID: 19632122]
Sf9 IC50
500 μM
Compound: 4
Inhibition of human CDK2/ Cyclin A catalytic subunit expressed in Sf9 insect cells assessed as histone H1 phosphorylation-associated depletion in ATP level by luminescence assay
Inhibition of human CDK2/ Cyclin A catalytic subunit expressed in Sf9 insect cells assessed as histone H1 phosphorylation-associated depletion in ATP level by luminescence assay
[PMID: 19632122]
体外研究
(In Vitro)

Fascaplysin induces autophagy as a cytoprotective response via ROS and p8 in vascular endothelial cells (VECs)[2].
Fascaplysin targets metabolic activity of the prostate cancer cells, without disrupting cell membrane's integrity[2].
. Fascaplysin induces caspase mediated crosstalk between apoptosis and autophagy through the inhibition of PI3K/AKT/mTOR signaling cascade in human leukemia HL-60 cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Fascaplysin 相关抗体:
体内研究
(In Vivo)

Fascaplysin suppresses the growth of S180 cell-implanted tumors in vivo[2]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

306.75

Formula

C18H11ClN2O
CAS 号
结构分类
初始来源

sponge
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Fascaplysin 相关分类

  • 摩尔计算器

  • 稀释计算器

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fascaplysin114719-57-2ApoptosisAutophagyReactive Oxygen SpeciesS180 cellHL-60 cellsVascular endothelial cells (VECs)LeukemiaAnti-tumor activityInhibitorinhibitorinhibit

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