1. 天然产物
  2. 植物 生物碱 酚类
  3. 桑科
  4. 大麻
  5. Feruloyl tyramine

Feruloyl tyramine 是一种酰胺化合物,能够从大麻籽乙醇提取物中分离得到。侧脑室注射 Feruloyl tyramine 可导致小鼠体温过低和运动失调。

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Feruloyl tyramine Chemical Structure

Feruloyl tyramine Chemical Structure

CAS No. : 65646-26-6

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Feruloyl tyramine, an amide compound, can be isolated from ethanol extract of hemp seed. Feruloyl tyramine injected into the lateral ventricle caused hypothermia and dyskinesia in mice[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
> 30 μM
Compound: 7
Cytotoxicity against human A549 cells by SRB assay
Cytotoxicity against human A549 cells by SRB assay
[PMID: 22951040]
A549 IC50
> 40 μM
Compound: 24
Antiproliferative activity against human A549 cells after 3 days by SRB assay
Antiproliferative activity against human A549 cells after 3 days by SRB assay
[PMID: 25241925]
A549 ED50
13.35 μg/mL
Compound: 6
Cytotoxicity against human A549 cells after 7 days
Cytotoxicity against human A549 cells after 7 days
[PMID: 1593281]
BV-2 IC50
17.36 μM
Compound: 7
Antiinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced NO production treated 30 mins before LPS stimulation measured after 24 hrs by Griess reaction
Antiinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced NO production treated 30 mins before LPS stimulation measured after 24 hrs by Griess reaction
[PMID: 22951040]
BV-2 IC50
18 μM
Compound: 21
Antineuroinflammatory activity against mouse BV2 cells assessed as inhibition of LPS-induced NO production incubated for 20 hrs by Griess assay
Antineuroinflammatory activity against mouse BV2 cells assessed as inhibition of LPS-induced NO production incubated for 20 hrs by Griess assay
[PMID: 33822610]
DU-145 IC50
> 40 μM
Compound: 24
Antiproliferative activity against human DU145 cells after 3 days by SRB assay
Antiproliferative activity against human DU145 cells after 3 days by SRB assay
[PMID: 25241925]
Erythrocyte IC50
0.88 mM
Compound: 25
Anticomplement activity in sheep erythrocytes assessed as concentration required for 50% hemolytic inhibition by classic pathway pretreated for 10 mins with guinea pig serum followed by erythrocyte addition measured after 30 mins by spectrophotometeric me
Anticomplement activity in sheep erythrocytes assessed as concentration required for 50% hemolytic inhibition by classic pathway pretreated for 10 mins with guinea pig serum followed by erythrocyte addition measured after 30 mins by spectrophotometeric me
[PMID: 29631958]
Erythrocyte IC50
1.33 mM
Compound: 25
Anticomplement activity in rabbit erythrocytes assessed as concentration required for 50% hemolytic inhibition by alternative pathway pretreated for 10 mins with normal human serum followed by erythrocyte addition measured after 30 mins by spectrophotomet
Anticomplement activity in rabbit erythrocytes assessed as concentration required for 50% hemolytic inhibition by alternative pathway pretreated for 10 mins with normal human serum followed by erythrocyte addition measured after 30 mins by spectrophotomet
[PMID: 29631958]
GES1 IC50
> 150 μM
Compound: 14
Antiproliferative activity against human GES1 cells assessed as reduction in cell viability after 24 hrs by MTT assay
Antiproliferative activity against human GES1 cells assessed as reduction in cell viability after 24 hrs by MTT assay
[PMID: 35286954]
HCT-15 IC50
> 30 μM
Compound: 7
Cytotoxicity against human HCT15 cells by SRB assay
Cytotoxicity against human HCT15 cells by SRB assay
[PMID: 22951040]
HepG2 IC50
6.6 μg/mL
Compound: 6
Cytotoxicity against human HepG2 cells by MTT assay
Cytotoxicity against human HepG2 cells by MTT assay
[PMID: 11374955]
HepG2 2.2.15 IC50
1.9 μg/mL
Compound: 6
Cytotoxicity against human HepG2(2.2.15) cells by MTT assay
Cytotoxicity against human HepG2(2.2.15) cells by MTT assay
[PMID: 11374955]
HGC-27 IC50
84.5 μM
Compound: 14
Antiproliferative activity against human HGC-27 cells assessed as reduction in cell viability after 24 hrs by MTT assay
Antiproliferative activity against human HGC-27 cells assessed as reduction in cell viability after 24 hrs by MTT assay
[PMID: 35286954]
HT-29 IC50
> 20 μM
Compound: 17
Cytotoxicity against human HT-29 cells assessed as reduction in cell growth incubated for 72 hrs
Cytotoxicity against human HT-29 cells assessed as reduction in cell growth incubated for 72 hrs
[PMID: 26147490]
HT-29 ED50
23.58 μg/mL
Compound: 6
Cytotoxicity against human HT-29 cells after 7 days
Cytotoxicity against human HT-29 cells after 7 days
[PMID: 1593281]
KB IC50
> 40 μM
Compound: 24
Antiproliferative activity against human KB cells after 3 days by SRB assay
Antiproliferative activity against human KB cells after 3 days by SRB assay
[PMID: 25241925]
KB IC50
> 47.8 μM
Compound: 12
Cytotoxicity against human KB cells by sulforhodamine B assay
Cytotoxicity against human KB cells by sulforhodamine B assay
[PMID: 26928423]
LNCaP IC50
> 100 μM
Compound: 5
Cytotoxicity against human LNCAP cells after 48 hrs by MTT assay
Cytotoxicity against human LNCAP cells after 48 hrs by MTT assay
[PMID: 11858758]
MCF7 IC50
> 40 μM
Compound: 24
Antiproliferative activity against human MCF7 cells after 3 days by SRB assay
Antiproliferative activity against human MCF7 cells after 3 days by SRB assay
[PMID: 25241925]
MCF7 ED50
4.76 μg/mL
Compound: 6
Cytotoxicity against human MCF7 cells after 7 days
Cytotoxicity against human MCF7 cells after 7 days
[PMID: 1593281]
MDA-MB-231 IC50
> 40 μM
Compound: 24
Antiproliferative activity against human MDA-MB-231 cells after 3 days by SRB assay
Antiproliferative activity against human MDA-MB-231 cells after 3 days by SRB assay
[PMID: 25241925]
MDA-MB-435 IC50
> 20 μM
Compound: 17
Cytotoxicity against human MDA-MB-435 cells assessed as reduction in cell growth incubated for 72 hrs
Cytotoxicity against human MDA-MB-435 cells assessed as reduction in cell growth incubated for 72 hrs
[PMID: 26147490]
MGC-803 IC50
98.3 μM
Compound: 14
Antiproliferative activity against human MGC-803 cells assessed as reduction in cell viability after 24 hrs by MTT assay
Antiproliferative activity against human MGC-803 cells assessed as reduction in cell viability after 24 hrs by MTT assay
[PMID: 35286954]
RAW264.7 IC50
> 50 μM
Compound: 25
Antiinflammatory activity in mouse RAW264.7 assessed as inhibition of LPS-induced NO production preincubated for 30 mins followed by LPS stimulation measured after 24 hrs by Griess reagent based assay
Antiinflammatory activity in mouse RAW264.7 assessed as inhibition of LPS-induced NO production preincubated for 30 mins followed by LPS stimulation measured after 24 hrs by Griess reagent based assay
[PMID: 33939429]
RAW264.7 IC50
6.33 μM
Compound: 9
Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced PGE2 production preincubated for 1 hr followed by LPS-stimulation and measured after 18 hrs
Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced PGE2 production preincubated for 1 hr followed by LPS-stimulation and measured after 18 hrs
[PMID: 31126853]
SK-BR-3 IC50
> 40 μM
Compound: 24
Antiproliferative activity against human SK-BR-3 cells after 3 days by SRB assay
Antiproliferative activity against human SK-BR-3 cells after 3 days by SRB assay
[PMID: 25241925]
SK-MEL-2 IC50
> 30 μM
Compound: 7
Cytotoxicity against human SK-MEL-2 cells by SRB assay
Cytotoxicity against human SK-MEL-2 cells by SRB assay
[PMID: 22951040]
SK-OV-3 IC50
> 30 μM
Compound: 7
Cytotoxicity against human SKOV3 cells by SRB assay
Cytotoxicity against human SKOV3 cells by SRB assay
[PMID: 22951040]
Vero IC50
> 47.8 μM
Compound: 12
Cytotoxicity against African green monkey Vero cells by sulforhodamine B assay
Cytotoxicity against African green monkey Vero cells by sulforhodamine B assay
[PMID: 26928423]
ZR-75-1 IC50
> 40 μM
Compound: 24
Antiproliferative activity against human ZR-75-1 cells after 3 days by SRB assay
Antiproliferative activity against human ZR-75-1 cells after 3 days by SRB assay
[PMID: 25241925]
体内研究
(In Vivo)

Feruloyl tyramine (133 μg/mouse, 200 μg/mouse; 侧脑室注射; 单次剂量) 可导致可导致小鼠体温过低和运动失调[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

313.35

Formula

C18H19NO4

CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

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产品名称:
Feruloyl tyramine
目录号:
HY-N11021
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