2. Anti-infection Metabolic Enzyme/Protease
  3. SARS-CoV Cathepsin Virus Protease
  4. FGA145

FGA145 是 Mpro 和人 Cathepsin L 的双效抑制剂，对于 Mal-Mpro，pET21-Mpro 和 Cathepsin L 的 Kis 分别为 3.71 μM，9.82 μM 和 53 nM。FGA145 具有多靶点的抗病毒活性。

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FGA145 Chemical Structure

FGA145 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
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FGA145 相关抗体

Top Publications Citing Use of Products

查看 Cathepsin 亚型特异性产品:

查看所有亚型
Cathepsin B Cathepsin C Cathepsin D Cathepsin E Cathepsin K Cathepsin L Cathepsin S

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

FGA145 is a dual, selective inhibitor for Mpro and human Cathepsin L, with Kis of 3.71 μM, 9.82 μM and 53 nM, for Mal-Mpro, pET21-Mpro and Cathepsin L, respectively. FGA145 reveals a multitarget effects in the antiviral activity[1].

IC50 & Target

cathepsin L

53 nM (Ki)

Cathepsin B

206 nM (Ki)

体外研究
(In Vitro)

FGA145 对 SARS-CoV-2 具有较弱的抗病毒活性，EC50 为 11.7 μM，在 Huh-7-ACE2 细胞中毒性低 (CC50 高于 100μM)[1]。
FGA145 对半胱氨酸蛋白酶 RhD，CRZ，Cat L 和 Cat B 表现出抑制作用，Kis 分别为 1.63，12.6，53 和 206 nM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

FGA145 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: Huh-7-ACE2
Concentration: 0-100 μM
Incubation Time: 24 h
Result: Exhibited a CC50 of over 100 μM.
分子量

442.51

Formula

C23H30N4O5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

FGA145 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FGA145FGA 145FGA-145SARS-CoVCathepsinVirus ProteaseSARS coronavirusSARS-CoV-2Huh-7-ACE2pMal-Mpro vectorpET21-Mpro vectorInhibitorinhibitorinhibit

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产品名称：
FGA145
目录号：
HY-161244
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