2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease Cell Cycle/DNA Damage
  3. Reactive Oxygen Species DNA/RNA Synthesis
  4. FLDP-5

FLDP-5 是一种具有血脑屏障透过性的姜黄素类似物。FLDP-5 可诱导活性氧 (ROS) 的产生、DNA 损伤和细胞周期 S 期阻滞。FLDP-5 对 LN-18 细胞具有抗增殖和抗迁移活性，具有很强的肿瘤抑制作用。

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FLDP-5 Chemical Structure

FLDP-5 Chemical Structure

CAS No. : 950665-12-0

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FLDP-5 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

FLDP-5 is a blood-brain barrier (BBB) penetrant curcuminoid analogues. FLDP-5 can induce production of ROS (Reactive Oxygen Species), DNA damage and cell cycle S phase arrest. FLDP-5 exhibits highly potent tumour-suppressive effects with anti-proliferative and anti-migratory activities on LN-18 cells[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
C6 IC50
3.9 μM
Compound: 14
Antiproliferative activity against rat C6 cells after 72 hrs by MTT assay
Antiproliferative activity against rat C6 cells after 72 hrs by MTT assay
[PMID: 20831222]
Caco-2 IC50
0.2 μM
Compound: 14
Antiproliferative activity against human Caco-2 cells after 72 hrs by MTT assay
Antiproliferative activity against human Caco-2 cells after 72 hrs by MTT assay
[PMID: 20831222]
HaCaT IC50
3 μM
Compound: 14
Antiproliferative activity against human HaCaT cells after 72 hrs by MTT assay
Antiproliferative activity against human HaCaT cells after 72 hrs by MTT assay
[PMID: 20831222]
HT-22 IC50
3.1 μM
Compound: 14
Antiproliferative activity against mouse HT22 cells after 72 hrs by MTT assay
Antiproliferative activity against mouse HT22 cells after 72 hrs by MTT assay
[PMID: 20831222]
NB-4 IC50
0.4 μM
Compound: 231
Cytotoxicity against human NB4 cells assessed as reduction in cell viability after 72 hrs by MTS assay
Cytotoxicity against human NB4 cells assessed as reduction in cell viability after 72 hrs by MTS assay
[PMID: 24960549]
NIH3T3 IC50
4.2 μM
Compound: 14
Antiproliferative activity against BALB/c mouse 3T3 cells after 72 hrs by MTT assay
Antiproliferative activity against BALB/c mouse 3T3 cells after 72 hrs by MTT assay
[PMID: 20831222]
SH-SY5Y IC50
2.1 μM
Compound: 14
Antiproliferative activity against human SH-SY5Y cells after 72 hrs by MTT assay
Antiproliferative activity against human SH-SY5Y cells after 72 hrs by MTT assay
[PMID: 20831222]
体外研究
(In Vitro)

FLDP-5 (0-20 μM; 24 h) has cytotoxicity on human glioblastoma multiforme (GBM) LN-18 cells and HBEC-5i[1].
FLDP-5 (2.5 μM; 0-6 h) induces superoxide and hydrogen peroxide in LN-18 cell death[1].
FLDP-5 (2.5 μM; 0-4 h) induces DNA damage with a time-dependent manner in LN-18 cells[1].
FLDP-5 (1.25 and 2.5 μM; 24 and 48 h) potentiates anti-migration effects in LN-18 cells[1].
FLDP-5 (1.25 and 2.5 μM; 24 h) reduces the percentage of relative invasion in LN-18 cells in a significant dose-dependent manner[1].
FLDP-5 (0.625 and 1.25 μM; 24 h) induces arrest in S phase in a concentration-dependent manner[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

FLDP-5 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: LN-18 and HBEC-5i cells
Concentration: 0-20 μM
Incubation Time: 24 h
Result: Exhibited cytotoxicity on human GBM LN-18 cells and HBEC-5i with IC50s of 2.4 μM and 5.6 μM.

Cell Migration Assay [1]

Cell Line: LN-18 cells
Concentration: 1.25 and 2.5 μM
Incubation Time: 24 and 48 h
Result: Potentiated anti-migration effects in LN-18 cells with wound closure of 56.43% ± 6.28 and 3.17% ± 0.71 at 1.25 μM and 2.5 μM (48 h), respectively.

Cell Invasion Assay[1]

Cell Line: LN-18 cells
Concentration: 1.25 and 2.5 μM
Incubation Time: 24 h
Result: Reduced the percentage of relative invasion in LN-18 cells in a significant dose-dependent manner.

Cell Cycle Analysis[1]

Cell Line: LN-18 cells
Concentration: 0.625 and 1.25 μM
Incubation Time: 24 h
Result: Induced arrest in S phase in a concentration-dependent manner, and exhibited accumulation of 63.38% ± 4.42 at 1.25 μM.
分子量

367.40

Formula

C21H21NO5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

FLDP-5 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FLDP-5950665-12-0FLDP5FLDP 5Reactive Oxygen SpeciesDNA/RNA SynthesisAnticancerLN-18glioblastoma multiformeDNA damagetumouranti-proliferativeanti-migratoryInhibitorinhibitorinhibit

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