2. Protein Tyrosine Kinase/RTK
  3. FLT3
  4. FLT3D835Y/F691L-IN-1

FLT3D835Y/F691L-IN-1 (compd 8v) 是口服有效的 FLT3 3-酪氨酸激酶域 D835Y/F691L 继发突变的抑制剂 (IC50 为 1.5 和 9.7 nM)。FLT3D835Y/F691L-IN-1 可用于急性髓系白血病的研究。

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FLT3D835Y/F691L-IN-1 Chemical Structure

FLT3D835Y/F691L-IN-1 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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FLT3D835Y/F691L-IN-1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

FLT3D835Y/F691L-IN-1 (compd 8v) is an orally active inhibitor of FLT3 3-tyrosine kinase domain D835Y/F691L secondary mutations with IC50s of 1.5 and 9.7 nM. FLT3D835Y/F691L-IN-1 can be used for acute myeloid leukemia research[1].

体外研究
(In Vitro)

FLT3D835Y/F691L-IN-1 (0.16-100 nM, 4 h) 抑制 p-FLT3 和细胞周期相关蛋白 CDK4/6 和 Cyclin D3，也抑制转染了 FLT3-ITD、FLT3-ITD-D835Y、FLT3-ITD-F691L、FLT3-ITD-D835Y-F691L 的 Ba/F3 细胞和 MV4-11 急性髓系白血病细胞系 (IC50 值分别为 12.2、10.5、24.6、16.9 和 6.8 nM) 的增殖[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

FLT3D835Y/F691L-IN-1 相关抗体:
体内研究
(In Vivo)

FLT3D835Y/F691L-IN-1 (30 mg/kg, 口服, 每日一次共 28 天) 抑制 Ba/F3-FLT3-ITD-D835Y 异种移植模型小鼠的肿瘤体积[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

511.62

Formula

C26H37N7O4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

FLT3D835Y/F691L-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FLT3D835Y/F691L-IN-1FLT3Cluster of differentiation antigen 135CD135Fms like tyrosine kinase 3FLT3 3-TKDD835Y/F691Lacute myeloid leukemiaBa/F3Inhibitorinhibitorinhibit

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