Folic acid-¹³C₆  (Synonyms: 叶酸-¹³C₆; Vitamin B9-¹³C₆; Vitamin M-¹³C₆)

Folic acid-13C6 is a deuterated labeled Folic acid^[1]. Folic acid (Vitamin B9) is a orally active essential nutrient from the B complex group of vitamins. Folic acid shows antidepressant-like effect. Folic acid sodium reduces the risk of neonatal neural tube defects. Folic acid can be used to the research of megaloblastic and macrocytic anemias due to folic deficiency^[2][3][4][5].

氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注，因为它可能影响药物的药代动力学和代谢谱^[1]。
Folic acid 在预防染色体断裂和 DNA 低甲基化方面起着关键作用^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Folic acid 在预防染色体断裂和 DNA 低甲基化方面起着关键作用^[2]。

Folic acid (10、50、100 mg/kg；口服) 在该行为小鼠模型中显示出抗抑郁样作用^[3]。
Folic acid (1、10 nmol/位点) 对适应新环境的小鼠没有精神刺激作用^[3]。
Folic acid (1、5 mg/kg；口服) 可防止大鼠后代肝脏基因表达的表观遗传修饰^[4]。大鼠口服叶酸水溶液时，AUC 为 1.4 μg h/mL，口服生物利用度为 35%^[6]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

447.35

C₁₃¹³C₆H₁₉N₇O₆

161406-20-8

59-30-3

叶酸-¹³C₆；维生素 B9-¹³C₆； 维生素 M-¹³C₆

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  [Content Brief]

  [2]. Butterworth CE Jr, et al. Folic acid safety and toxicity: a brief review. Am J Clin Nutr. 1989 Aug;50(2):353-8.  [Content Brief]

  [3]. Peñalva R, et al. Zein nanoparticles for oral folic acid delivery[J]. Journal of Drug Delivery Science and Technology, 2015, 30: 450-457.

  [4]. Brocardo PS, et al. Folic acid administration produces an antidepressant-like effect in mice: evidence for the involvement of the serotonergic and noradrenergic systems. Neuropharmacology. 2008 Feb;54(2):464-73.  [Content Brief]

  [5]. Aparicio-Trejo OE, et al. Chronic impairment of mitochondrial bioenergetics and β-oxidation promotes experimental AKI-to-CKD transition induced by folic acid. Free Radic Biol Med. 2020 Jul;154:18-32.  [Content Brief]

  [6]. Lillycrop KA, et al. Dietary protein restriction of pregnant rats induces and folic acid supplementation prevents epigenetic modification of hepatic gene expression in the offspring. J Nutr. 2005 Jun;135(6):1382-6.  [Content Brief]

  [7]. Pietrzik K, et al. Folic acid and L-5-methyltetrahydrofolate: comparison of clinical pharmacokinetics and pharmacodynamics. Clin Pharmacokinet. 2010 Aug;49(8):535-48.  [Content Brief]