2. GPCR/G Protein Neuronal Signaling
  3. Neurokinin Receptor
  4. FR 113680

FR 113680 是一种三肽 substance P 拮抗剂，可选择性与 NK1 神经激肽受体相互作用。

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Custom Peptide Synthesis

FR 113680 Chemical Structure

FR 113680 Chemical Structure

CAS No. : 126088-92-4

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FR 113680 相关抗体

Top Publications Citing Use of Products

查看 Neurokinin Receptor 亚型特异性产品:

查看所有亚型
NK1 NK2 NK3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

FR 113680 is a tripeptide substance P antagonist that interacts selectively with the NK1 neurokinin receptor[1].

体外研究
(In Vitro)

FR 113680 对 SP 诱导的豚鼠回肠收缩具有竞争性抑制作用，pA2 值为 7.53[1]。
FR 113680 对 [3H]-SP 结合大鼠大脑皮质膜 (NK1)、[3H]-神经激肽 A ([3H]-NKA) 结合大鼠十二指肠平滑肌膜 (NK2) 和 [3H]-eledoisin (Ele) 结合大鼠大脑皮质膜 (NK3) 无影响[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

FR 113680 相关抗体:
体内研究
(In Vivo)

FR 113680 (32 mg/kg; i.v.; once) 显著抑制香烟烟雾引起的血浆外渗[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats, cigarette smoke-induced rat tracheal plasma extravasation model[2]
Dosage: 0, 10 and 32 mg/kg
Administration: IV, once
Result: Significantly inhibited cigarette smoke-induced rat tracheal plasma extravasation at a dose of 32 mg/kg.
分子量

625.71

Formula

C35H39N5O6
CAS 号
Sequence

Ac-Thr-{d-Trp(For)}-{Phe(NMe,Bzl)}
Sequence Shortening

Ac-T-{d-Trp(For)}-{Phe(NMe,Bzl)}
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

FR 113680 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FR 113680126088-92-4FR113680FR-113680Neurokinin ReceptorNK receptorTachykinin receptorInhibitorinhibitorinhibit

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产品名称：
FR 113680
目录号：
HY-105436
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