2. GPCR/G Protein
  3. Bradykinin Receptor
  4. FR173657

FR173657 是一种具有口服活性的缓激肽 B2 受体拮抗剂 (IC50: 对猪、大鼠、人 B2 受体分别为 0.56、1.5、2.9 nM)。 FR173657 (p.o.) 抑制 BK 诱导的豚鼠支气管收缩 (ED50: 0.075 mg/kg)。FR173657 (p.o.) 还可抑制角叉菜胶诱导的小鼠爪水肿 (ED50: 6.8 mg/kg)。FR173657可用于炎症性疾病的研究。

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FR173657 Chemical Structure

FR173657 Chemical Structure

CAS No. : 167838-64-4

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FR173657 相关抗体

Top Publications Citing Use of Products

查看 Bradykinin Receptor 亚型特异性产品:

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Bradykinin B1 Receptor (B1R) Bradykinin B2 Receptor (B2R)

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

FR173657 is an orally active bradykinin B2 receptor antagonist (IC50: 0.56, 1.5, 2.9 nM for pig, rat, human B2 receptor respectively). FR173657 (p.o.) inhibits BK-induced bronchoconstriction in guinea-pigs (ED50: 0.075 mg/kg). FR173657 (p.o.) also inhibits Carrageenin-induced paw oedema in mice (ED50: 6.8 mg/kg). FR173657 can be used for research of inflammatory disease[1].

IC50 & Target

0.56, 1.5, 2.9 nM for pig, rat, human B2 receptor respectively[1]
分子量

592.47

Formula

C30H27Cl2N5O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

FR173657 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FR173657167838-64-4FK-3657FR 173657FR-173657FK3657FK 3657Bradykinin Receptorpaw oedemabronchoconstrictionCarrageeninanti-inflammatoryInhibitorinhibitorinhibit

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产品名称：
FR173657
目录号：
HY-15791
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