2. Apoptosis
  3. c-Myc
  4. FUBP1-IN-2

FUBP1-IN-2 (compound 9) 是一种有效的 FUBP1 (远上游结合蛋白 1) 抑制剂。在凝胶移位试验中，FUBP1-IN-2 抑制 KH4 FUBP1-FUSE 相互作用。FUBP1-IN-2 在 ChIP 试验中与 FUBP1 结合。FUBP1-IN-2 可降低 c-Myc mRNA 和蛋白表达，增加 p21 mRNA 和蛋白表达，并消耗细胞内多胺。

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FUBP1-IN-2 Chemical Structure

FUBP1-IN-2 Chemical Structure

CAS No. : 1242862-71-0

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FUBP1-IN-2 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

FUBP1-IN-2 (compound 9) is a potent FUBP1 (far upstream binding protein 1) inhibitor. FUBP1-IN-2 inhibits the KH4 FUBP1-FUSE interaction in a gel shift assay. FUBP1-IN-2 binds to FUBP1 in a ChIP assay. FUBP1-IN-2 reduces both c-Myc mRNA and protein expression, increases p21 mRNA and protein expression, and depletes intracellular polyamines[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
CHO-K1 EC50
> 40 μM
Compound: 9; 0754479
Inhibition of spermidine uptake chinese hamster CHO-K1 cells assessed as decrease in cell growth by measuring cellular ATP content measured after 48 hrs in presence of DFMO and spermidine by ATPlite assay
Inhibition of spermidine uptake chinese hamster CHO-K1 cells assessed as decrease in cell growth by measuring cellular ATP content measured after 48 hrs in presence of DFMO and spermidine by ATPlite assay
[PMID: 36382923]
CHO-K1 EC50
8 μM
Compound: 9; 0754479
Inhibition of polyamine uptake in chinese hamster CHO-K1 cells assessed as rescue of Ant44-induced toxicity by measuring cellular ATP content measured after 48 hrs in presence of Ant44 and aminoguanidine by ATPlite assay
Inhibition of polyamine uptake in chinese hamster CHO-K1 cells assessed as rescue of Ant44-induced toxicity by measuring cellular ATP content measured after 48 hrs in presence of Ant44 and aminoguanidine by ATPlite assay
[PMID: 36382923]
L3.6pl IC50
16.8 μM
Compound: 9; 0754479
Cytotoxicity against human L3.6pl cells cells assessed as inhibition of cell growth measured after 72 hrs by ATPlite assay
Cytotoxicity against human L3.6pl cells cells assessed as inhibition of cell growth measured after 72 hrs by ATPlite assay
[PMID: 36382923]
体外研究
(In Vitro)

FUBP1-IN-2 (compound 9) does not inhibit 3 H-spermidine uptake yet works synergistically with Eflornithine (HY-B0744) to limit cell growth in the presence of exogenous spermidine[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

FUBP1-IN-2 相关抗体:
分子量

479.96

Formula

C26H26ClN3O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

FUBP1-IN-2 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

FUBP1-IN-21242862-71-0c-MycMycCHO-K1 cellsFUBP1far upstream binding protein 1FUBP1-FUSEp21polyaminesInhibitorinhibitorinhibit

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目录号：
HY-151884
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