2. Anti-infection
  3. Antibiotic Dengue virus Flavivirus
  4. GAK inhibitor 2

GAK inhibitor 2 (Compound 14g) 是一种有效的细胞周期蛋白 G 相关激酶 (GAK) 抑制剂，IC50 为 0.024 μM。GAK inhibitor 2 具有抗病毒活性，对登革热病毒的 EC50 为 1.049 μM。

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GAK inhibitor 2 Chemical Structure

GAK inhibitor 2 Chemical Structure

CAS No. : 2396706-31-1

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GAK inhibitor 2 相关抗体

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  • 生物活性

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生物活性

GAK inhibitor 2 (Compound 14g) is a potent cyclin G-associated kinase (GAK) inhibitor with an IC50 of 0.024 μM. GAK inhibitor 2 shows antiviral activity with an EC50 of 1.049 μM against dengue virus (DENV)[1].

IC50 & Target

IC50: 0.024 μM (GAK)[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
Huh-7 CC50
> 10 μM
Compound: 14g
Cytotoxicity against human HuH7 cells assessed as reduction in cell viability incubated for 48 hrs by alamar blue reagent based cell viability assay
Cytotoxicity against human HuH7 cells assessed as reduction in cell viability incubated for 48 hrs by alamar blue reagent based cell viability assay
[PMID: 31757682]
Huh-7 EC50
1.049 μM
Compound: 14g
Antiviral activity against Dengue virus 2 infected in human HuH7 cells incubated for 48 hrs by luciferase reporter gene assay
Antiviral activity against Dengue virus 2 infected in human HuH7 cells incubated for 48 hrs by luciferase reporter gene assay
[PMID: 31757682]
分子量

385.48

Formula

C20H23N3O3S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

GAK inhibitor 2 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GAK inhibitor 22396706-31-1GAK inhibitor2GAK inhibitor-2AntibioticDengue virusFlavivirusDENVantiviraldengue virusInhibitorinhibitorinhibit

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