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Ganciclovir triphosphate  (Synonyms: GCV-TP)

目录号: HY-131605
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Ganciclovir triphosphate (GCV-TP)是一种合成的2'-脱氧鸟苷类似物，具有抑制人类巨细胞病毒（CMV）复制的活性。Ganciclovir triphosphate通过与病毒DNA聚合酶结合，干扰病毒DNA的合成，从而对CMV感染有效。Ganciclovir triphosphate的半数有效浓度（IC50）为0.01 μM，且对来自人类、猴子、鼠类和豚鼠的CMV株具有良好的抗病毒效果。Ganciclovir triphosphate在基因导向酶前药抑制中也被应用，用于癌症抑制。

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Ganciclovir triphosphate Chemical Structure

Ganciclovir triphosphate Chemical Structure

CAS No. : 86761-38-8

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生物活性

Ganciclovir triphosphate (GCV-TP) is a synthetic 2'-deoxyguanosine analog with activity in inhibiting human cytomegalovirus (CMV) replication. Ganciclovir triphosphate is effective against CMV infection by binding to viral DNA polymerase and interfering with viral DNA synthesis. Ganciclovir triphosphate has an IC50 of 0.01 μM and has good antiviral effects against CMV strains from humans, monkeys, mice, and guinea pigs. Ganciclovir triphosphate has also been used in gene-directed enzyme prodrug inhibition for cancer inhibition[1].

分子量

495.17

Formula

C9H16N5O13P3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
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Ganciclovir triphosphate 相关分类

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Keywords:

Ganciclovir triphosphate86761-38-8GCV-TPOthersInhibitorinhibitorinhibit

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