CDH10 - cadherin 10 Gene

中文名称：钙粘蛋白 10

种属: Homo sapiens

关于 CDH10

功能概要

该基因编码钙粘蛋白超家族的 II 型经典钙粘蛋白。该基因的可变剪接导致多个转录变体。这些变体中至少有一个编码一种前原蛋白，该蛋白经过蛋白水解处理后生成成熟的钙粘蛋白。这些完整的膜蛋白介导钙依赖性细胞粘附，由一个大的 N 末端细胞外结构域、一个跨膜结构域和一个小的、高度保守的 C 末端胞质结构域组成。细胞外结构域由 5 个子结构域组成，每个子结构域包含一个钙粘蛋白基序，并且似乎决定了该蛋白质的嗜同细胞粘附活性的特异性。 II 型 (非典型) 钙粘蛋白是根据它们缺乏 I 型钙粘蛋白特有的组氨酸-丙氨酸-缬氨酸 (HAV) 细胞粘附识别序列来定义的。这种特殊的钙粘蛋白主要在大脑中表达，并被推定参与突触粘连、轴突生长和引导。该基因的突变可能与人类患者的肺鳞状细胞癌和结直肠癌有关。[RefSeq 提供，2015 年 11 月]

This gene encodes a type II classical cadherin of the cadherin superfamily. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature cadherin protein. These integral membrane proteins mediate calcium-dependent cell-cell adhesion and are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of 5 subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein's homophilic cell adhesion activity. Type II (atypical) Cadherins are defined based on their lack of a histidine-alanine-valine (HAV) cell adhesion recognition sequence specific to type I Cadherins. This particular cadherin is predominantly expressed in brain and is putatively involved in synaptic adhesions, axon outgrowth and guidance. Mutations in this gene may be associated with lung squamous cell carcinoma and colorectal Cancer in human patients. [provided by RefSeq, Nov 2015]