1. Gene
  2. CDH13 - cadherin 13 Gene

CDH13 - cadherin 13 Gene

中文名称:钙粘蛋白 13

种属: Homo sapiens

同用名: CDHH; P105

基因 ID: 1012 | 基因类型: protein coding

关于 CDH13

Cytogenetic location: 16q23.3 Genomic coordinates (GRCh38): 16:82,626,969-83,800,640 (from NCBI)

This gene has 14 transcripts (splice variants), 205 orthologues and 33 paralogues. Broad expression in endometrium (RPKM 22.0), heart (RPKM 17.7) and 16 other tissues.

功能概要

该基因编码钙粘蛋白超家族的一个成员。编码的蛋白质位于细胞膜表面,并由 GPI 部分锚定,而不是跨膜结构域。该蛋白缺乏其他钙粘蛋白的细胞质结构域特征,因此不被认为是细胞间粘附糖蛋白。这种蛋白质在神经分化过程中充当轴突生长的负调节剂。它还保护血管内皮细胞免受氧化应激引起的细胞凋亡,并与抗动脉粥样硬化有关。该基因在许多类型的癌症中都被高度甲基化。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供,2011 年 5 月]

This gene encodes a member of the cadherin superfamily. The encoded protein is localized to the surface of the cell membrane and is anchored by a GPI moiety, rather than by a transmembrane domain. The protein lacks the cytoplasmic domain characteristic of other Cadherins, and so is not thought to be a cell-cell adhesion glycoprotein. This protein acts as a negative regulator of axon growth during neural differentiation. It also protects vascular endothelial cells from Apoptosis due to oxidative stress, and is associated with resistance to atherosclerosis. The gene is hypermethylated in many types of Cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2011]

CDH13 基因产物(6)

mRNA Protein Name
NM_001220488.2 NP_001207417.1 cadherin-13 isoform 2
NM_001220489.2 NP_001207418.1 cadherin-13 isoform 3 precursor
NM_001220490.2 NP_001207419.1 cadherin-13 isoform 4
NM_001220491.2 NP_001207420.1 cadherin-13 isoform 5 precursor
NM_001220492.2 NP_001207421.1 cadherin-13 isoform 6 precursor
NM_001257.5 NP_001248.1 cadherin-13 isoform 1 preproprotein
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cadherin binding IDA
IDA: 通过直接分析推断
10601632 GOA
enables lipoprotein particle binding IDA
IDA: 通过直接分析推断
11027617 GOA
enables low-density lipoprotein particle binding IDA
IDA: 通过直接分析推断
16013438 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32814053 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in Rac protein signal transduction IMP
IMP: 通过突变表型推断
15703273 GOA
involved in Rho protein signal transduction IMP
IMP: 通过突变表型推断
15703273 GOA
involved in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IDA
IDA: 通过直接分析推断
10601632 GOA
involved in endothelial cell migration IDA
IDA: 通过直接分析推断
14729458 GOA
involved in homophilic cell adhesion via plasma membrane adhesion molecules IDA
IDA: 通过直接分析推断
10601632 GOA
involved in keratinocyte proliferation IDA
IDA: 通过直接分析推断
15816843 GOA
involved in lamellipodium assembly IDA
IDA: 通过直接分析推断
15703273 GOA
involved in localization within membrane IMP
IMP: 通过突变表型推断
17573778 GOA
involved in low-density lipoprotein particle mediated signaling IDA
IDA: 通过直接分析推断
16013438 GOA
involved in negative regulation of cell adhesion IDA
IDA: 通过直接分析推断
14729458 GOA
involved in negative regulation of cell population proliferation IDA
IDA: 通过直接分析推断
10737605 GOA
involved in positive regulation of calcium-mediated signaling IDA
IDA: 通过直接分析推断
16013438 GOA
involved in positive regulation of cell migration IDA
IDA: 通过直接分析推断
14729458 GOA
involved in positive regulation of cell-matrix adhesion IMP
IMP: 通过突变表型推断
17573778 GOA
involved in positive regulation of endothelial cell proliferation IMP
IMP: 通过突变表型推断
15364621 GOA
involved in positive regulation of positive chemotaxis IDA
IDA: 通过直接分析推断
16013438 GOA
involved in positive regulation of smooth muscle cell proliferation IMP
IMP: 通过突变表型推断
15364621 GOA
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
16099944 GOA
involved in regulation of endocytosis IMP
IMP: 通过突变表型推断
17573778 GOA
involved in regulation of epidermal growth factor receptor signaling pathway IMP
IMP: 通过突变表型推断
17573778 GOA
involved in sprouting angiogenesis IDA
IDA: 通过直接分析推断
16873731 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in caveola IDA
IDA: 通过直接分析推断
9650591 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
10737605 GOA
located in extracellular space IDA
IDA: 通过直接分析推断
16873731 GOA
located in neuron projection IDA
IDA: 通过直接分析推断
10737605 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
10737605 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

CDH13 蛋白结构

Cadherin_pro

Cadherin_pro: Cadherin prodomain like (73 - 156)

Cadherin

Cadherin: Cadherin domain (193 - 282)

Cadherin

Cadherin: Cadherin domain (299 - 400)

Cadherin

Cadherin: Cadherin domain (415 - 516)

Cadherin

Cadherin: Cadherin domain (534 - 622)

Cadherin

Cadherin: Cadherin domain (636 - 727)

  • 0
  • 200
  • 400
  • 600
  • 760 a.a.
蛋白主名 其他名称

cadherin-13

H-cadherin (heart)

关联疾病

疾病名称 别名
Vacterl Association

Vater Association

Vater Syndrome

Familial Adenomatous Polyposis

Adenomatous Polyposis Coli

Fap

Familial Polyposis Coli

Familial Multiple Polyposis Syndrome

Adenomatous Polyposis Of The Colon

Familial Intestinal Polyposis

Fpc

Familial Adenomatous Polyposis Of The Colon

Familial Multiple Polyposis

Familial Polyposis Of The Colon

Hereditary Polyposis Coli

Polyposis, Adenomatous Intestinal

Adenomatous Familial Polyposis

Adenomatous Familial Polyposis Syndrome

Myh-Associated Polyposis

Colorectal Adenomatous Polyposis

Adenomatous Polyposis, Familial

Mutyh-Associate Polyposis

Seminoma

Seminoma, Pure

Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma

Bilateral Breast Cancer

Bilateral Breast Carcinoma

Endometrial Cancer

Endometrial Carcinoma

Endometrial Neoplasm

Malignant Neoplasm Of Endometrium

Endometrioid Carcinoma

Endometrial Neoplasms

Carcinoma, Endometrioid

Endometrial Cancer, Familial

Endometrial Carcinoma, Somatic

Endometrial Cancer, Susceptibility To

Endometrial Ca

Malignant Endometrial Neoplasm

Neoplasm Of Endometrium

Primary Malignant Neoplasm Of Endometrium

Tumor Of Endometrium

Carcinoma Of The Endometrium

Endometrioid Carcinoma Of Female Reproductive System

ENDMC

Carcinoma Endometrioid

Endometrial Cancers

Cancer, Endometrial

Uterine Corpus Cancer

Cervical Cancer

Cervical Cancer, Somatic

Neoplasm Of Uterine Cervix

Cervix Cancer

Uterine Cervical Neoplasm

Cervical Neoplasm

Cervix Uteri Cancer

Tumor Of The Cervix Uteri

CERCA

Uterine Cervical Cancer

Neoplasms Cervical

Uterine Cervical Neoplasms

Cervical Cancers

Cancer, Cervical, Somatic

Malignant Tumor Of Cervix

Cervix Carcinoma

Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon

Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Cancer Of The Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor

OC

Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary

Scoliosis
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer

Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder

ADHD

Attention Deficit Disorder

Attention Deficit-Hyperactivity Disorder, Susceptibility To

Attention Deficit Disorder With Hyperactivity

Hyperkinetic Disorder

Hyperactivity Of Childhood

Attention-Deficit/Hyperactivity Disorder

Add

Addh

Attention Deficit

Attention Deficit Disorder Of Childhood With Hyperactivity

Attention Deficit Disorder With Hyperactivity Syndrome

Hyperkinetic Syndrome

Attention-Deficit Hyperactivity Disorder

Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type

Disturbance Of Activity And Attention

Disorder Of Activity And Attention

Adhd - [Attention Deficit Hyperactivity Disorder]

Hyperkinetic Disorders

Disorder Of Activity And Attention With Hyperkinesia

Attention Deficit Syndrome With Hyperactivity

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Bos taurus CDH13 VGNC VGNC:27093
Mus musculus CDH13 MGD MGI:99551
Rattus norvegicus CDH13 RGD RGD:619745
Macaca mulatta CDH13 VGNC VGNC:70807
Canis familiaris CDH13 VGNC VGNC:39022
Others CDH13 NCBI