PDIA6 - protein disulfide isomerase family A member 6 Gene

中文名称：蛋白质二硫键异构酶家族 A 成员 6

种属: Homo sapiens

同用名: P5; ERP5; TXNDC7

关于 PDIA6

功能概要

该基因编码内质网 (ER) 蛋白二硫化物异构酶 (PDI) 家族的成员，该蛋白催化蛋白质折叠和硫醇-二硫化物交换反应。编码的蛋白质具有一个 N 端 ER 信号序列、两个具有催化活性的硫氧还蛋白 (TRX) 结构域、一个 TRX 样结构域和一个 C 端 ER 保留序列。这种蛋白质抑制错误折叠蛋白质的聚集，并表现出异构酶和分子伴侣活性。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2016 年 12 月]

This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, two catalytically active thioredoxin (TRX) domains, a TRX-like domain, and a C-terminal ER-retention sequence. This protein inhibits the aggregation of misfolded proteins and exhibits both isomerase and chaperone activity. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]