2. Gene
  3. CDH16 - cadherin 16 Gene

CDH16 - cadherin 16 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：钙粘蛋白 16

种属: Homo sapiens

基因 ID: 1014 | 基因类型: protein coding

关于 CDH16

Cytogenetic location: 16q22.1 Genomic coordinates (GRCh38): 16:66,908,122-66,918,885 (from NCBI)

Restricted expression toward kidney (RPKM 177.1).

功能概要

该基因是钙粘蛋白超家族的成员，该基因编码钙依赖性膜相关糖蛋白。映射到染色体 16q22.1 上先前确定的钙粘蛋白基因簇，该基因定位于超家族成员 CDH1、CDH3、CDH5、CDH8 和 CDH11。该蛋白质由含有 6 个钙粘蛋白结构域的胞外结构域、一个跨膜区和一个截短的细胞质结构域组成，但缺乏大多数经典钙粘蛋白典型的原序列和三肽 HAV 粘附识别序列。表达完全在肾脏中，其中蛋白质作为同型细胞识别的主要介质，在组织发育的形态发生方向中发挥作用。已经鉴定出编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2011 年 3 月]

This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. Mapped to a previously identified cluster of cadherin genes on chromosome 16q22.1, the gene localizes with superfamily members CDH1, CDH3, CDH5, CDH8 and CDH11. The protein consists of an extracellular domain containing 6 cadherin domains, a transmembrane region and a truncated cytoplasmic domain but lacks the prosequence and tripeptide HAV adhesion recognition sequence typical of most classical Cadherins. Expression is exclusively in kidney, where the protein functions as the principal mediator of homotypic cellular recognition, playing a role in the morphogenic direction of tissue development. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011]

CDH16 基因产物(4)

mRNA Protein Name
NM_001204744.2 NP_001191673.1 cadherin-16 isoform 2 precursor
NM_001204745.2 NP_001191674.1 cadherin-16 isoform 3 precursor
NM_001204746.2 NP_001191675.1 cadherin-16 isoform 4 precursor
NM_004062.4 NP_004053.1 cadherin-16 isoform 1 precursor

CDH16 蛋白结构

Cadherin

Cadherin: Cadherin domain (133 - 231)

Cadherin

Cadherin: Cadherin domain (267 - 324)

Cadherin

Cadherin: Cadherin domain (342 - 439)

Cadherin

Cadherin: Cadherin domain (457 - 555)

  • 0
  • 200
  • 400
  • 600
  • 829 a.a.
蛋白主名 其他名称

cadherin-16

KSP-cadherin

重组 CDH16 蛋白

目录号 产品名 蛋白编号 纯度
HY-P73507 CDH16 Protein, Human (HEK293, His) O75309/NP_004053.1 (K19-A786) ≥95%

关联疾病

疾病名称 别名
Oncocytoma

Oxyphilic Adenoma

Follicular Adenoma, Oxyphilic Cell

Adenoma, Oxyphilic

Hurthle Cell Tumor

Oncocytic Neoplasm
Renal Cell Carcinoma, Nonpapillary

Renal Cell Carcinoma

RCC

Nonpapillary Renal Cell Carcinoma

Clear Cell Renal Cell Carcinoma

Hypernephroma

Adenocarcinoma Of Kidney

Renal Carcinoma, Chromophobe, Somatic

Clear Cell Carcinoma Of Kidney

Clear-Cell Metastatic Renal Cell Carcinoma

Clear Cell Renal Carcinoma

Renal Cell Carcinoma, Somatic

Conventional Renal Cell Carcinoma

Conventional Renal Cell Carcinoma

Renal Clear Cell Carcinoma

Ccrcc

Hereditary Clear Cell Renal Cell Carcinoma

Carcinoma, Renal Cell

Renal Cell Carcinoma, Clear Cell, Somatic

Renal Cell Carcinoma, Clear Cell

Clear Cell Kidney Carcinoma

Clear Cell Rcc

Cystic-Multilocular Variant

Clear Cell Renal Cell Adenocarcinoma

Hereditary Clear Cell Renal Cell Adenocarcinoma

Common Renal Cell Carcinoma

Crcc

Renal Cell Carcinoma Non-Papillary

Carcinoma Renal Cell

Renal Cell Cancer

Carcinoma, Renal Cell, Nonpapillary
Eosinophilic Variant Of Chromophobe Renal Cell Carcinoma
Renal Oncocytoma

Oncocytoma, Renal

Oncocytoma Of Kidney

Renal Epithelial Oncocytic Tumor

Oncocytoma Kidney

Oncocytoma Renal

Kidney Oncocytoma
Multilocular Clear Cell Renal Cell Carcinoma

Cystadenocarcinoma Of Kidney

Renal Cystadenocarcinoma
Fetal Adenoma

Microfollicular Adenoma
Epithelial Predominant Wilms' Tumor

Epithelial Predominant Kidney Adenosarcoma

Epithelial Predominant Renal Wilms Tumor

Epithelial Predominant Renal Wilms Tumour

Epithelial Predominant Wilms' Tumour
Kidney Benign Neoplasm

Renal And Ureteral Tumor

Benign Kidney Neoplasm
Collecting Duct Carcinoma

Kidney Medullary Carcinoma

Renal Medullary Carcinoma

Bdc

Bellini Carcinoma

Bellini Duct Carcinoma

Cdc

Collecting Duct Carcinoma Of The Kidney

Renal Cell Adenocarcinoma

Carcinoma Of Renal Collecting Duct

Renal Carcinoma, Collecting Duct Type

Renal Cell Carcinoma

Bellini'S Duct Carcinoma

Renal Collecting Duct Carcinoma

Adenocarcinoma Of Kidney
Renal Adenoma

Renal Cell Adenoma
Birt-Hogg-Dube Syndrome

Hornstein-Knickenberg Syndrome

Fibrofolliculomas With Trichodiscomas And Acrochordons

BHD

Birt-Hogg-Dubé Syndrome

Multiple Fibrofolliculoma Familial

Bhd Syndrome

Birt Hogg Dube Syndrome

Hornstein-Birt-Hogg-Dubé Syndrome

Multiple Fibrofolliculomas
Chromophobe Renal Cell Carcinoma

Chromophobe Adenocarcinoma

Chromophobe Carcinoma Of Kidney

Kidney Chromophobe

Renal Cell Carcinoma, Chromophobe Cell

Crcc

Chrcc

Chromophobe Renal Cell Adenocarcinoma

Chromophobe Renal Carcinoma

Chromophobe Carcinoma
Renal Cell Carcinoma, Papillary, 1

Papillary Renal Cell Carcinoma

Hereditary Papillary Renal Cell Carcinoma

Papillary Renal Cell Carcinoma, Sporadic

Papillary Renal Cell Adenocarcinoma

RCCP

RCCP1

Renal Cell Carcinoma, Papillary

Renal Cell Carcinoma, Papillary, 1, Familial And Somatic

Chromophil Carcinoma Of Kidney

Papillary Kidney Carcinoma

Sporadic Papillary Renal Cell Carcinoma

Chromophil Renal Cell Carcinoma

Papillary Renal Carcinoma, Malignant -

Papillary Renal Cell Carcinoma, Bilateral -

Papillary Renal Cell Carcinoma, Familial -

Papillary Renal Cell Carcinoma, Multiple -

Papillary Renal Cell Carcinoma, Sporadic -

Renal Adenocarcinoma

Chromophil Rcc

Hprcc

Renal Cell Carcinoma Papillary

Chromophilic Renal Cell Carcinoma

Prcc

Carcinoma, Renal Cell, Papillary, Type 1

Type 1 Papillary Renal Cell Carcinoma

Renal Cell Carcinoma

Hereditary Papillary Renal Carcinoma
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS02326 CDH16 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus CDH16 VGNC VGNC:60674
Macaca mulatta CDH16 VGNC VGNC:70809
Rattus norvegicus CDH16 RGD RGD:1311638
Mus musculus CDH16 MGD MGI:106671
Canis familiaris CDH16 VGNC VGNC:39024
Bos taurus CDH16 VGNC VGNC:27095
Macaca fascicularis CDH16 NCBI NCBI:102116872
Others CDH16 NCBI
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