2. Gene
  3. EBI3 - Epstein-Barr virus induced 3 Gene

EBI3 - Epstein-Barr virus induced 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：爱泼斯坦-巴尔病毒诱导 3

种属: Homo sapiens

同用名: IL27B; IL35B; IL-27B

基因 ID: 10148 | 基因类型: protein coding

关于 EBI3

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:4,229,523-4,237,528 (from NCBI)

This gene has 2 transcripts (splice variants), 192 orthologues and 23 paralogues. Biased expression in placenta (RPKM 82.3), spleen (RPKM 9.3) and 2 other tissues.

功能概要

该基因是通过其在 B 淋巴细胞中响应 Epstein-Barr 病毒感染而诱导表达来鉴定的。它编码一种属于造血素受体家族的分泌型糖蛋白，并与一种 28 kDa 的蛋白质异二聚化形成白细胞介素 27 (IL-27) 。 IL-27 调节 T 细胞和炎症反应，部分是通过激活 CD4+ T 细胞的 JAK/STAT 通路。[RefSeq 提供，2008 年 9 月]

This gene was identified by its induced expression in B lymphocytes in response Epstein-Barr virus Infection. It encodes a secreted glycoprotein belonging to the hematopoietin receptor family, and heterodimerizes with a 28 kDa protein to form interleukin 27 (IL-27). IL-27 regulates T cell and inflammatory responses, in part by activating the JAK/STAT pathway of CD4+ T cells. [provided by RefSeq, Sep 2008]

EBI3 基因产物(1)

mRNA Protein Name
NM_005755.3 NP_005746.2 interleukin-27 subunit beta precursor

EBI3 蛋白结构

fn3

fn3: Fibronectin type III domain (130 - 209)

  • 0
  • 100
  • 200
  • 229 a.a.
蛋白主名 其他名称

interleukin-27 subunit beta

EBV-induced gene 3 protein

重组 EBI3 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70338 IL-35 Protein, Human (HEK293, Fc) P29459 (R23-S219)&Q14213 (R21-K229) ≥95%
HY-P73199 IL-27 Protein, Human (CHO, His) Q14213 (R21-K229)&Q8NEV9 (F29-P243) ≥95%
HY-P73880 IL-35 Protein, Human (HEK293, Flag-His) P29459 (R23-S219)&Q14213 (R21-K229) ≥95%
HY-P73882 IL-35 Protein, Human (HEK293, His-hFc-Myc) P29459 (R23-S219)&Q14213 (R21-K229) ≥95%
HY-P700118AF Animal-Free IL-27 beta/EBI3 Protein, Human (His) Q14213 (R21-K229) ≥95%

关联疾病

疾病名称 别名
Sialadenitis

Sialoadenitis

Adenitis, Salivary Gland

Salivary Gland Inflammation

Salivary Gland Adenitis

Sialitis

Inflammation Of Salivary Gland

Inflammation Of Salivary Duct Or Gland

Salivary Glandular Adenitis

Sialoangiitis

Sialoangitis

Sialodochitis
Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory
Autoimmune Disease

Autoimmune Diseases

Autoimmune Hypersensitivity Disease

Hypersensitivity Reaction Type Ii Disease

Type Ii Hypersensitivity Reaction Disease
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04128 EBI3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus EBI3 RGD RGD:1589467
Mus musculus EBI3 MGD MGI:1354171
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